针刀联合奥美拉唑镁肠溶片在治疗反流性食管炎中对胃食管反流病诊断问卷、内镜、自主神经的影响

Effects of needle knife and Losec on RDQ,endoscope and autonomic nerve in the treatment of reflux esophagitis

目的:观察对照组及治疗组在治疗反流性食管炎中分别对胃食管反流病诊断问卷(Reflux Disease Questionnaire,RDQ)、内镜分级、自主神经功能的影响。方法:分析东莞台心医院和广东省中医院被诊断为反流性食管炎(Reflux Esophagitis,RE)的患者184例,采用随机数字表法将其分为对照组91例,予奥美拉唑镁肠溶片治疗,每日20 mg,每日1次,餐前服药,对有夜间症状、不同作息时间和∕或睡眠障碍者,可予每日2次给药,治疗周期为8周;治疗组93例,在使用奥美拉唑镁肠溶片的同时,配合针刀治疗,每周1次,治疗8次,两组疗程均为8周;6个月后,电话随访,观察两组远期疗效。结果:在RDQ疗效上,治疗组总有效率(96.7%,89/92)高于对照组(90.1%,81/91);在内镜疗效上,治疗组总有效率(94.6%,87/92)高于对照组(87.9%,80/91);在自主神经功能上,治疗组低频功率(Low Frequency,LF)和高频功率(High Frequency,HF)变化明显,两组分析比较,差异有统计学意义(P<0.05)。结论:针刀配合奥美拉唑镁肠溶片在治疗反流性食管炎病中的临床效果显著,值得推广应用。

Objective:To observe the effects of the control group and the treatment group on the reflux disease questionnaire(RDQ)questionnaire,endoscopic classification,and autonomic nerve function in the treatment of reflux esophagitis respectively.Methods:A total of 184 patients diagnosed with reflux esophagitis(RE)in Dongguan Taixin Hospital were analyzed and divided into a control group of 91 patients by random number table method.They were treated with Losec(Omeprazole magnesium enteric-coated tablets)at 20 mg/d,once daily,and taken before meals.For patients with night symptoms,different sleep schedules and/or sleep disorders,medication may be administered twice daily for 8 weeks;In the treatment group,93 patients were treated with Losec and needle knife at the same time,once a week and there were 8 times of treatment,both of which lasted for 8 weeks.After 6 months,telephone follow-up was conducted to observe the long-term efficacy of the two groups.Results:In the efficacy of RDQ,the total effective rate of the treatment group(96.7%,89/92)was higher than that of the control group(90.1%,81/91);in terms of internal efficacy,the total effective rate of the treatment group(94.6%,87/92)was higher than that of the control group(87.9%,80/91);In terms of autonomic nerve function,the changes of LF and HF in the treatment group were significant.Comparing the analysis of the two groups,P<0.05 showed a significant difference.Conclusion:The clinical effect of needle knife combined with Losec is significant in the treatment of reflux esophagitis,and it is worth popularizing and applying.