7例凝血因子Ⅻ缺乏症患者临床报道和文献复习

Coagulation factor Ⅻ deficiency:Clinical report of 7 patients and literature review

目的回顾性分析2016年2月~2020年1月就诊于本院的凝血因子Ⅻ缺乏症7例病例患者临床表现、实验室特征,以提高对此类疾病诊治方法的认识。方法对7例病例凝血因子Ⅻ缺乏患者的临床资料进行分析,并复习相关文献。结果 7例患者均以APTT明显延长为主要表现,无出血、血栓表现,有1例有阳性家族史,有1例为肿瘤继发的获得性凝血因子Ⅻ缺乏症。结论临床工作中APTT延长但无出血表现患者需全面筛查相关内外源凝血因子和获得性因素非常必要,以避免漏诊,误诊以及过度治疗。

Objective To retrospectively analyze the clinical manifestations and laboratory characteristics of 7 patients with coagulation factorⅫdeficiency in our hospital from February 2016 to January 2020 in order to improve the understanding of diagnosis and treatment for the diseases.Methods The clinical data of 7 patients with coagulation factorⅫdeficiency were analyzed,and related literatures were reviewed.Results All the 7 patients showed significantly prolonged APTT without bleeding or thrombosis.Among them,1 had a positive family history,and 1 acquired coagulation factorⅫdeficiency secondary to the tumor.Conclusion It is very necessary to comprehensively screen related internal and external coagulation factors and acquired factors in patients with prolonged APTT but no bleeding,so as to avoid missed diagnosis,misdiagnosis and over treatment.