新型抗真菌药艾沙康唑的研究进展

Research Progress of Isavuconazole,a New Antifungal Agent

艾沙康唑是新型三唑类抗真菌药物,尚未在中国上市。艾沙康唑抗菌谱广,体外研究和临床试验提示对霉菌、酵母菌、双向真菌及一些罕见真菌等均有抗菌活性;对特殊部位,如中枢神经系统的感染临床治疗有效;其血药浓度稳定,安全性和耐受性好,长期使用药物相关不良反应少。综述艾沙康唑的药理学特征和临床研究进展,以期为临床用药提供参考。

Isavuconazole is a novel triazole antifungal agent that has not yet been marketed in China.It has a broad antifungal spectrum.In vitro studies and clinical trials have shown that it’s active against molds,yeasts,dimorphic fungi and some rare fungi,that it is effective for clinical treatment of infection at special sites such as the central nervous system,and that the blood concentration of isavuconazole is stable,with good safety and tolerability,and with fewer adverse events during long-term use.This review summarizes the pharmacological characteristics and clinical research progress of isavuconazole,aiming to provide reference for clinical medication.