水貂冠状病毒研究进展

Research Progress on Mink Coronavirus

水貂冠状病毒(Mink coronavirus,MCoV)属于冠状病毒科α冠状病毒属的成员,通常会引起以卡他性腹泻为主要症状的水貂流行性卡他性胃肠炎(Mink epizootic catarrhal gastroenteritis,ECG)。该病已在各国许多貂场暴发,给养貂业造成巨大经济损失。本文总结了自1975年报道ECG以来,水貂冠状病毒的研究进展,包括MCoV的基因组结构、遗传进化分析、受体特点及ECG的诊断及防治,以期引起人们对水貂冠状病毒的重视,为水貂冠状病毒病的防控提供参考。

Mink coronavirus(MCoV),a member of Coronaviridae,Alphacoronavirus,is an important pathogenic agent of Mink epizootic catarrhal gastroenteritis(ECG),which is characterized by catarrhal diarrhea in minks.ECG has broken out in many mink farms in several countries and caused serious threats to minks.This article reviews the research progress on ECG reported since 1975,including the genomic structure,genetic evolution and receptor characteristics of MCoV,diagnosis,prevention and treatment of ECG.This review will provide reference for clinical prevention and treatment of ECG,and arouse people's attention to MCoV.