高危型人乳头瘤病毒基因多态性研究进展

Gene Polymorphisms of High-risk Human Papillomaviruses:A Review

高危型人乳头瘤病毒已被证实是宫颈癌发生发展的必要因素,但不同型别的流行特征存在广泛的区域差异性,且即使是同一型别,其基因组同样存在基因多态性。这些基因多态性可能导致蛋白质功能的差异,进而造成病毒生存能力,致病能力以及与宿主细胞相互作用的差异。现已有大量研究表明HPV16和HPV18型基因多态性在病毒的生物学功能和导致临床疾病进展具有重要意义,因此更多的相关研究围绕着HPV高危型中不同型别的基因多态性相继开展,本文对高危型人乳头瘤病毒HPV16,HPV18,HPV58,HPV52,HPV31和HPV33型的基因多态性研究现状加以综述。

High-risk human papillomaviruses(HPVs)have been shown to be necessary factors for the development of cervical cancer.However,the epidemiological characteristics of different types of papillomaviruses show wide regional differences.Even in the same type,there are also genetic polymorphisms in the genome.Differences in these genes are likely to result in differences in proteins,which leads to differences in viral viability,pathogenicity,and interaction with host cells.Several studies have shown that the gene polymorphisms of HPV16 and HPV18 have biological and clinical importance.Therefore,the genetic polymorphisms of high-risk HPVs are garnering considerable attention,and many related studies are being carried out in different types of HPVs.Here,we review recent results of genetic polymorphisms in high-risk HPV16,HPV18,HPV58,HPV52,HPV31 and HPV33.