妊娠合并肺动脉高压的发病机制及性激素的作用

Pathogenesis of Pregnancy with Pulmonary Hypertension and Role of Sex Hormones

肺动脉高压是一种发病机制多样的致死性疾病。它会引起严重的血流动力学紊乱、严重的肺血管重塑、肺血管阻力增加、右心衰竭,最终导致死亡。女性的发病率远高于男性。即使在应用现代先进的靶向药物治疗后死亡率仍明显下降,但由于仍存在让人难以接受的极高的产妇和胎儿死亡率,指南中禁止肺动脉高压患者怀孕。现旨在探讨妊娠合并肺动脉高压患者的发病机制及性激素在其中的作用。

Pulmonary hypertension is a kind of fatal disease with various pathogenesis.It can cause serious hemodynamic disorder,severe pulmonary vascular remodeling,increased pulmonary vascular resistance and right heart failure,and eventally lead to death.The incidence of women is much higher than that of men.Even after the application of modern and advanced targeted drugs,the mortality rate has decreased significantly,but due to the unacceptably high maternal and fetal mortality rate,pregnancy in patients with pulmonary hypertension is prohibited in the guidelines.This paper aims to explore the pathogenesis of pregnancy complicated with pulmonary hypertension and the role of sex hormones in it.