摘要
米非司酮是一种抗孕激素,最初用于终止早期妊娠,目前关于米非司酮其他适应证的研究越来越多且涉及较多病种。米非司酮的分子特性使之可能有若干适应证,故了解其安全性至关重要。经过多年的使用,米非司酮的有效性和安全性已得到一定的证实,也有了一些新的研究结果。本文综述了米非司酮在动物中进行的毒理学研究,以及在各种已经批准或未批准的适应证中使用该化合物所报告的安全性相关结果,包括男性志愿者重复给药研究、人类长期和非长期使用时的相关安全性研究结果等。
Mifepristone is an antiprogesterone drug,which was initially used for termination of early pregnancy.There are more and more studies on other indications of mifepristone,including the treatment of many diseases.The molecular characteristics of the drug make it possible to have several indications,so it is very important to understand the safety of mifepristone.The efficacy and safety of mifepristone has been confirmed based on its use over several decades while there are some new positions.This paper reviews the toxicological studies in animals and the safety of the use of this compound in various indications either approved or unapproved,including the researches of repeated administration in male volunteers,and long-term as well as non-long-term studies on the safety of mifepristone use in human.
作者
裴开颜
林静
刘爽
涂鹏程
PEI Kai-yan;LIN Jing;LIU Shuang;TU Peng-cheng(National Research Institute for Family Planning,Beijing 100081;National Health Commission Capacity Building and Continuing Education Center,Beijing 100089;Graduate School of Peking Union Medical College,Beijing 100730)
出处
《生殖医学杂志》
CAS
2021年第8期1113-1117,共5页
Journal of Reproductive Medicine
基金
国家重点研发计划(2016YFC1000905)。