献血频次对单采血小板献血者血清钙、镁和甲状旁腺素的影响

The Effect of Donation Frequency on Serum Calcium,Magnesium and Parathyroid Hormone Levels in Plateletpheresis Donors

目的了解血清镁在血小板单采过程中的变化情况及单采血小板献血者的献血频次对其血清钙、镁和甲状旁腺素的影响情况。方法选择本中心29名单采血小板固定献血者,根据献血频次高低分为两组,高频次组(n=16):献血次数>12次/年;低频次组(n=13):献血次数≤12次/年。分别检测献血者在血小板采集后0、30、60、90 min血液标本的血清钙、镁和甲状旁腺素水平,利用重复测量数据方差分析比较两组献血者的这三项指标的差异。结果血小板采集后时间点在0、30、60、90 min,高频次组和与低频次组献血者的血清钙(mmol/L)分别为2.41±0.23 vs.2.40±0.13、2.17±0.22 vs.2.26±0.11、2.20±0.24 vs.2.27±0.14、2.21±0.22 vs.2.28±0.18,均较0 min下降,下降程度从大到小依次为采集开始后30 min、60 min、90 min;血清镁(mmol/L)分别为0.76±0.18 vs.0.75±0.21、0.69±0.21 vs.0.71±0.21、0.70±0.19 vs.0.72±0.19、0.71±0.20 vs.0.73±0.18,变化趋势与血清钙基本类似;甲状旁腺素(pg/mL)分别为40.32±17.24 vs.60.35±58.80、138.87±63.55 vs.190.43±64.85、129.14±65.70 vs.162.68±47.19、89.00±63.85 vs.122.22±57.90,较采集开始时上升,上升程度从大到小依次为采集开始后第30 min、60 min、90 min。两组之间只有甲状旁腺素水平在30 min时为138.87±63.55 vs.190.43±64.85(P<0.05)。结论血清镁在血小板采集过程中存在降低的情况,而低献血频次的献血者的血清甲状旁腺素水平却会明显升高,应当引起各采供血机构的重视。

Objective To understand change of serum magnesium during plateletpheresis and the effect of donation frequency on serum calcium,magnesium and parathyroid hormone(PTH)in regular plateletpheresis donors.Methods A total of 29 plateletpheresis donors were divided into two groups based on their donation frequency:high frequency(n=16,>12 times per year),low frequency(n=13,≤12 times per year).Serum levels of calcium,magnesium and PTH in donors at 0 min,30 min,60 min,90 min of plateletpheresis were measured.The differences of the three markers between groups was analyzed by analysis of variance of repeated measurement data.Results The serum calcium(mmol/L)of donors in low frequency group and high frequency group at 0 min,30 min,60 min,90 min of plateletpheresis were 2.41±0.23 vs.2.40±0.13、2.17±0.22vs.2.26±0.11、2.20±0.24 vs.2.27±0.14、2.21±0.22 vs.2.28±0.18,respectively,and all of which decreased compared to the beginning of plateletpheresis,and the decreased levels was at 30 minutes,60 minutes,and 90 minutes after starting plateletpheresis.Serum magnesium(mmol/L)were 0.76±0.18 vs.0.75±0.21、0.69±0.21vs.0.71±0.21、0.70±0.19 vs.0.72±0.19、0.71±0.20 vs.0.73±0.18,respectively.The change trend was similar to that of serum calcium.Serum PTH(pg/mL)were 40.32±17.24 vs.60.35±58.80、138.87±63.55 vs.190.43±64.85、129.14±65.70 vs.162.68±47.19、89.00±63.85 vs.122.22±57.90,respectively,and all of which increased compared to the beginning of plateletpheresis.The increased levels was at 30 minutes,60 minutes,and 90 minutes after starting plateletpheresis.Only the PTH levels between the two groups were 138.87±63.55 vs.190.43±64.85 at 30 min of plateletpheresis(P<0.05).Conclusion Serum magnesium decreased,and PTH in donors with lower donation frequency significantly increased during plateletpheresis,which should arouse more attention of blood collection and supply institutions.