血清ACA、TIMP-1水平与急性脑梗死患者病情程度的关联性

Correlation of Serum Anticardiolipin Antibody,Tissue Inhibitor of Metalloproteinase-1 Levels and Severity of Acute Cerebral Infarction

目的分析血清抗心磷脂抗体(ACA)、金属蛋白酶组织抑制因子-1(TIMP-1)水平与急性脑梗死(ACI)患者病情程度的关联性,为ACI临床诊断及预后评估提供依据。方法选取2018年4月至2020年10月濮阳市人民医院收治的85例ACI患者作为研究对象,另选取同期50例健康体检者作为对照,检测入院次日ACI患者和健康体检者ACA阳性率,并比较入院次日不同美国国立卫生研究院卒中量表(NIHSS)评分、病灶数量以及入院后不同时间ACI患者ACA阳性率,检测ACI患者和健康体检者TIMP-1水平及入院次日不同NIHSS评分ACI患者TIMP-1水平。结果入院次日ACI患者ACA阳性率较健康体检者高(P<0.05)。入院次日不同NIHSS评分ACI患者ACA阳性率比较,差异有统计学意义,随NIHSS评分提高,ACA阳性率升高(P<0.05)。入院次日多发病灶ACI患者ACA阳性率(76.47%)较单发病灶患者(50.98%)高(P<0.05)。ACA阳性ACI患者连续4周ACA阳性率比较,差异有统计学意义,且呈下降趋势(P<0.05)。ACI患者入院次日及第1、2、3、4周TIMP-1水平均高于健康体检者(P<0.001),ACI患者TIMP-1水平随入院时间延长呈下降趋势(P<0.05)。入院次日不同NIHSS评分ACI患者TIMP-1水平比较,差异有统计学意义,随NIHSS评分提高,TIMP-1水平升高(P<0.05)。结论检测血清ACA、TIMP-1水平对评估ACI患者病情程度有积极作用,ACA阳性率高、TIMP-1水平高提示患者病情程度较重,可作为判断病情程度及短期预后的标志物。

Objective To analyze the correlation between serum anticardiolipin antibody(ACA),tissue inhibitor of metalloproteinase-1(TIMP-1)levels and severity of acute cerebral infarction(ACI),so as to provide evidence for the clinical diagnosis and prognosis evaluation of ACI.Methods A total of 85 patients with ACI from April 2018 to October 2020 in Puyang People’s Hospital were selected as the research subjects,and 50 healthy people with healthy physical examination during the same period were selected as controls.The positive rates of ACA in patients with ACI on the next day after admission and healthy people were detected,and the positive rates of ACA in patients with ACI with different NIHSS scores,number of lesions on the next day after admission and different time after admission were compared.The TIMP-1 levels in patients with ACI and healthy people were detected,and the TIMP-1 levels in patients with ACI with different NIHSS scores on the next day after admission were detected.Results The positive rate of ACA in patients with ACI on the next day after admission was higher than that in healthy people(P<0.05).There was a statistical difference in the positive rate of ACA among patients with ACI with different NIHSS scores(P<0.05),and the positive rate of ACA increased with the increase of NIHSS score(P<0.05).The positive rate(76.47%)of ACA in patients with ACI with multiple lesions was higher than that(50.98%)in patients with single lesion(P<0.05).There was a statistical difference in the positive rate of ACA in patients with ACI with ACA positive for 4 consecutive weeks,and the trend was decreasing(P<0.05).On the next day after admission and at 1,2,3,4 weeks,the TIMP-1 levels in patients with ACI were higher than those in healthy people(P<0.001),and the TIMP-1 level in patients with ACI showed a downward trend with the increase of admission time(P<0.05).There was a statistical difference in the TIMP-1 level among patients with ACI with different NIHSS scores on the next day after admission(P<0.05),and the TIMP-1 level increased with the increase of NIHSS score(P<0.05).Conclusion The detection of serum ACA and TIMP-1 levels has a positive effect on the assessment of the severity of ACI.The high positive rate of ACA and high TIMP-1 level indicate that the patient’s condition is more serious,which can be used as a marker for the severity of illness and short-term prognosis.