多叶棘豆化学成分的研究

Chemical constituents from Oxytropis myriophylla

目的研究多叶棘豆Oxytropis myriophylla(Pall)DC.的化学成分。方法多叶棘豆乙醇提取物采用硅胶、Sephadex LH⁃20、HP⁃20型大孔吸附树脂、MCI等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到15个化合物,分别鉴定为槲皮素⁃7⁃O⁃α⁃鼠李糖⁃3⁃O⁃(6″⁃反式咖啡酰)⁃β⁃D⁃吡喃葡萄糖基⁃(1→2)⁃β⁃吡喃葡萄糖苷(1)、brainoside B(2)、蒙花苷(3)、香叶木苷(4)、山柰酚⁃7⁃O⁃α⁃L⁃吡喃鼠李糖苷(5)、檞皮素⁃7⁃O⁃α⁃L⁃吡喃鼠李糖苷(6)、山柰酚(7)、槲皮素(8)、blumenol C glucoside(9)、D⁃3⁃O⁃甲基肌醇(10)、水杨酸(11)、原儿茶酸(12)、没食子酸(13)、β⁃谷甾醇(14)、胡萝卜苷(15)。结论化合物1~2、4~6、9~13为首次从该植物中分离得到。

AIM To study the chemical constituents from Oxytropis myriophylla(Pall)DC..METHODS The ethanol extract from O.myriophylla was isolated and purified by silica,Sephadex LH⁃20,HP⁃20 macroporous resin,and MCI,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Fifteen compounds were isolated and identified as quercetin⁃7⁃O⁃α⁃rhamnopyranosyl⁃3⁃O⁃(6″⁃trans⁃caffeoyl)⁃β⁃D⁃glucopyranosyl⁃(1→2)⁃β⁃glucopyranoside(1),brainoside B(2),linarin(3),diosmin(4),kaempferol⁃7⁃O⁃α⁃L⁃rhamnopyranoside(5),quercitrin⁃7⁃O⁃α⁃L⁃rhamnopyranoside(6),kaempferol(7),quercetin(8),blumenol C glucoside(9),D⁃3⁃O⁃methyl inositol(10),salicylic acid(11),protocatechuic acid(12),gallic acid(13),β⁃sitosterol(14),and daucosterol(15).CONCLUSION Compounds 1-2,4-6,9-13 are isolated from this plant for the first time.