化疗联合肠内营养支持对老年胃癌患者临床疗效及预后的影响

Effect of chemotherapy combined with enteral nutrition support on elderly patients with gastric cancer and their prognosis

目的探究化疗联合肠内营养支持对老年胃癌患者临床疗效及预后的影响。方法回顾性选取2018年1月~2020年1月收治的86例老年胃癌患者作为研究对象。根据治疗方式的不同将患者分为对照组和观察组,对照组给予常规化疗,观察组患者进行化疗联合肠内营养支持。比较两组患者治疗后临床疗效、营养指标、生活质量和预后生存情况。结果治疗后,观察组完全缓解患者13例,部分缓解18例,有效率为70.45%,高于对照组57.14%,但差异无统计学意义(P>0.05)。观察组患者营养相关指标体重、BMI、上臂肌围、血清总蛋白、白蛋白、血红蛋白分别为(55.09±3.67)kg、(21.03±1.35)kg/m^(2)、(26.54±2.23)cm、(61.49±4.65)g/L、(31.78±3.32)g/L、(133.54±9.63)g/L,均显著高于对照组;且生活质量也明显提高,差异均有统计学意义(P<0.05)。观察组患者1年的生存率为86.36%(38/44),高于对照组,但组间差异无统计学意义(P>0.05)结论化疗联合肠内营养支持有助于提高老年胃癌患者的临床治疗疗效,改善营养相关指标,提高生活质量,改善患者预后。

Objective To explore the effect of chemotherapy combined with enteral nutrition support on elderly patients with gastric cancer.Methods 86 elderly patients with gastric cancer admitted to our hospital were retrospectively selected as the research objects from January 2018 to January 2020.According to different treatment methods,the patients were divided into control group and observation group.The control group was given routine chemotherapy,and the observation group was received chemotherapy combined with enteral nutrition support.Clinical efficacy,nutritional indexes,quality of life and prognosis were compared between the two groups after treatment.Results After treatment,there were 13 cases of complete remission and 18 cases of partial remission in the observation group.The effective rate was 70.45%,which was higher than that 57.14%in the control group without statistically significant difference(P>0.05).The nutrition related indexes of the observation group such as body weight,BMI,upper arm muscle circumference,total albumin,serumalbumin and hemoglobinwere(55.09±3.67)kg,(21.03±1.35)kg/m^(2),(26.54±2.23)cm,(61.49±4.65)g/L,(31.78±3.32)g/L,(133.54±9.63)g/L,respectively,which were significantly higher than those of the control group.The quality of life was also significantly improved,and the differences were statistically significant(P<0.05).The 1-year survival rate in the observation group was 86.36%(38/44),which was higher than that in the control group,but the difference between two groups had no statistically significant(P>0.05).Conclusion Chemotherapy combined with enteral nutrition support can improve the clinical treatment efficiency of elderly patients with gastric cancer,enhance nutritional indexes and quality of life,and promote the prognosis of patients.