SAA在固有免疫防御感染中的作用机制

Mechanisms of SAA on innate immunity of defence infections

血清淀粉样蛋白A(SAA)家族由SAA1至SAA44个蛋白组成。作为急性时相反应(APR)蛋白,在机体受到创伤和感染等激发因素时,SAA1和SAA2可在血清中急剧增加,SAA可作为多种疾病诊断、预后和治疗的生物指标。SAA在机体各个组织中均可表达,在感染、固有免疫应答和非特异性炎症过程中具有多种作用。SAA的部分生物学功能目前尚未完全明确,但其在宿主防御中的重要作用已较为确定。近年来随着SAA研究的深入,发现其在感染免疫多种途径中发挥作用。本综述重点介绍SAA在固有免疫防御感染中的作用机制,对近10年SAA的重要进展进行综述,尤其是5年内的相关进展。

Serum amyloid A(SAA)protein family consists of 4 protein molecules from SAA1 to SAA4.As acute phase reaction(APR)proteins,SAA1 and SAA2 are increase dramatically in serum when the organism is subjected to stimuli factors such as trauma and infection.SAA can be used as a biomarker in diagnosis,prognosis and treatment for many diseases.SAA are proteins found in all tissues of life with a plethora of biological functions,especially in infection process,innate immune response,and nonspecific inflammation.Biological function of SAA is undetermined but its role in host defense is obvious.In recent years,with the sin-depth investigate on SAA,it has been found that it plays a role in infection immunity through various pathways.In this review,we highlight the most important interconnections between SAA and immunity,focusing on host defense against relevant infections and on the SAA mechanism of innate immunity.In this opinion article,an overview of the most important developments of SAA in the last decades with a focus on the last five years is given.