盐酸小檗碱对糖耐量减低患者脂肪细胞型脂肪酸结合蛋白的影响临床观察

The effects of berberine hydrochloride on adipocyte fatty acid binding protein in patients with IGT

目的:研究盐酸小檗碱对糖耐量减低(Impaired Glucose Tolerance,IGT)患者的脂肪细胞型脂肪酸结合蛋白(Adipocyte Fatty Acid-Binding Protein,A-FABP)的影响。方法:对照组22例采用安慰剂结合生活方式干预治疗;治疗组20例采用盐酸小檗碱结合生活方式干预治疗。主要观察治疗前后各组A-FABP变化并进行组间和组内比较。结果:治疗组治疗后与治疗前比较,A-FABP降低,差异有统计学意义(P<0.05);治疗后组间A-FABP比较,治疗组A-FABP较对照组低,差异有统计学意义(P<0.05)。结论:盐酸小檗碱能降低IGT患者的A-FABP水平。

Objective:To study the effects of berberine hydrochloride on adipocyte fatty acid binding protein in patients with IGT.Methods:22 cases in the control group were treated with placebo plus lifestyle intervention,and 20 cases in the treatment group were treated with berberine hydrochloride plus lifestyle intervention.Results:After treatment,A-FABP in the treatment group was decreased compared with before treatment,and the difference was statistically significant(P<0.05).After treatment,A-FABP in the treatment group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:Berberine hydrochloride can reduce the level of A-FABP in IGT patients.