自拟抑癌汤联合多西他赛化疗对去势抵抗前列腺癌的疗效观察

Efficacy of the Yiai decoction with docetaxel chemotherapy on castration resistance to prostate cancer

目的:探讨自拟抑癌汤联合多西他赛化疗对去势抵抗前列腺癌(Castration-Resistant Prostate Cancer,CRPC)的疗效。方法:选取2014年12月-2019年12月收治的CRPC患者36例进行研究,随机数字表法分为对照组与观察组各18例,对照组采用多西他赛化疗,观察组在对照组基础上加自拟抑癌汤,对两组治疗效果、疼痛程度、前列腺特异性抗原(Prostate Specific antigen,PSA)、肿瘤体积进行比较。结果:观察组治疗总有效率明显较对照组高(P<0.05);两组治疗前的视觉模拟评分法(Visual Analogue Scale,VAS)评分、PSA、肿瘤体积无明显差异(P>0.05),观察组治疗后上述指标与对照组比较有明显差异(P<0.05);观察组胃肠道反应、骨髓抑制等不良反应发生率明显低于对照组(P<0.05);治疗前两组卡氏评分(Karnofsky,KPS)无明显差异(P>0.05),观察组治疗后KPS评分均高于对照组,治疗后平均生存时间较对照组长(P<0.05)。结论:自拟抑癌汤联合多西他赛化疗治疗CRPC能提高疗效,改善临床相关指标,也能减少化疗不良反应发生率,值得推广。

Objective:To explore the effect of the Yiai decoction(抑癌汤)with docetaxel chemotherapy on castration resistance to prostate cancer.Methods:36 patients were divided into the control group and the observation group,18 cases in each.The control group was treated by docetaxel chemotherapy.The observation group was given the Yiai decoction more.Results:The total efficiency in the observation group was significantly higher than the control group(P<0.05).VAS,PSA and tumor volume in the observation group were better than those in the control group after treatment(P<0.05).The incidence of gastrointestinal reactions and bone marrow suppression in the observation group was lower than the control group(P<0.05).KPS in the observation group were higher than the control group,and the median survival time after treatment was longer than the control group(P<0.05).Conclusion:The Yiai decoction with docetaxel chemotherapy on castration-resistant prostate cancer was effective,can improve the clinical indicators,and reduce the incidence of chemotherapy toxicity,which is worthy of promotion.