基于中医传承辅助平台探讨中医药治疗银屑病关节炎的组方规律

Exploring Medication Regularities in Treating Psoriatic Arthritis Based on Traditional Chinese Medicine Inheritance Support System

目的探讨中医药治疗银屑病关节炎的组方用药规律。方法检索中国知网(CNKI)、万方数据知识服务平台(Wanfang)、维普中文期刊(VIP),收集运用中药方剂治疗银屑病关节炎的文献,采用中医传承辅助平台(V2.5)软件分析其用药规律。结果共筛选到方剂92首,涉及药物206味,其中使用频次较高的药物有当归、秦艽、甘草、地黄、赤芍等;用药以清热药、补虚药、祛风湿药、活血化瘀药、解表药为主,尤为注重治血;药性以寒、温、平为主;药味以苦、甘、辛为主;归经以肝经为主,然后依次为胃、心、脾、肺、肾经等;常用药对有"当归-秦艽""当归-地黄""甘草-当归""川芎-当归""当归-防风"等;通过复杂系统熵聚类分析提取出2种不同的核心组合各5组,并挖掘出潜在新方5首。结论通过数据挖掘的方法,总结了银屑病关节炎治疗的用药规律,挖掘到新处方5首,可为临床治疗提供参考。

Objective To analyze the rule of Chinese medicine in the treatment of psoriatic arthritis,and to provide a reference for clinical selection of medication.Methods The databases of CNKI,Wanfang and VIP were searched,the relevant literatures published before May 2020 were collected and the prescriptions for treating psoriatic arthritis were extracted according to the established standards.The traditional Chinese medicine inheritance support system(V2.5)was used to analyze medication regularities.Results A total of 56 literatures and 92 prescriptions were selected,including 206 herbs,among which the five most frequently used were Angelica sinensis,Gentiana macrophylla,Glycyrrhiza uralensis,Radix rehmannia,Radix paeonia Rubra.The drugs mainly focus on heat-clearing medicinals,tonifying and replenishing medicinals,blood-activating medicinals,antirheumatism medicinals,and exterior-releasing medicinals,with particular attention to the treatment of blood.The natures of the drugs were mostly cold,warm and flat,and the flavors were mainly bitter,sweet and spicy.The meridian tropisms of the most frequently used drugs were composed of liver,stomach,heart,spleen,lung,kidney meridians.The commonly used drug pairs are Angelica sinensis and Gentiana macrophylla,Angelica sinensis and Radix rehmannia,Glycyrrhiza uralensis and Angelica sinensis,Chuanxiong rhizome and Angelica sinensis,Angelica sinensis and Saposhnikovia divaricata.Based on the hierarchical clustering analysis of complex system entropy clustering,two different core combinations(5 groups in each group)and 5 potential new prescriptions were obtained.Conclusion Through the method of data mining,the rules of medication for treating psoriatic arthritis have been summarized.The new prescriptions can provide reference for clinic practice.