健脾祛浊消积颗粒在晚期结直肠癌化疗患者中的应用效果分析

Efficacy of Late Colorectal Cancer Patients Orally Administering Jianpi Quzhuo Xiaoji Keli Amidst Chemotherapy

为探讨健脾祛浊消积颗粒在晚期结直肠癌化疗患者中的应用效果,将2018年1月至2020年1月于我院接受FOLFIRI方案化疗的78例晚期结直肠癌患者随机分为观察组和对照组,各39例,化疗过程中,观察组口服健脾祛浊消积颗粒,对照组口服安慰剂。比较2组患者治疗前后腹痛腹胀、便溏、体倦乏力、食少纳呆等中医证候积分,以及总体疗效。结果显示,治疗后,对照组患者腹痛腹胀、体倦乏力、食少纳呆积分均较治疗前有所降低,但差异无统计学意义(P>0.05),便溏积分明显升高(P<0.05);而观察组患者治疗后腹痛腹胀、便溏、体倦乏力、食少纳呆积分均较治疗前明显降低(P<0.05)。2组治疗后各中医证候积分比较,观察组积分均明显低于对照组,P<0.05。观察组总有效率明显高于对照组,P<0.05。观察组化疗不良反应发生率明显低于对照组,P<0.05。结果表明,健脾祛浊消积颗粒有助于缓解晚期结直肠癌化疗者的临床症状,降低化疗不良反应发生率,减轻患者痛苦。

This study was to observe the efficacy of late colorectal cancer patients orally administering Jianpi Quzhuo Xiaoji Keli(a TCM formula,shortly named as Granule)amidst chemotherapy,randomly divided 78 late colorectal cancer patients who received FOLFIRI schema in author’s hospital(2018-01-2020-01)into observation group(39 cases,amidst chemotherapy orally administered Granule)and control group(39 cases,placebo);then,compared both group’s patients’TCM syndrome accumulated ratings on abdominal pain,burbulence,loose stool,hyposthenia,and anorexia,etc,as well as whole effect.As results,after treatment in accumulated ratings on abdominal pain and burbulence,loose stool,hyposthenia,and anorexia observation group was significantly declined than before treatment(P<0.05),but in control group except for loose stool ratings was significantly lifted(P<0.05);though other items was some declined than before treatment,but had no statistical difference(P>0.05);after treatment all TCM syndrome ratings accumulated points in observation group were significantly lower than that in control group(P<0.05);in total effective rate observation group was significantly higher than control group(P<0.05);and,in the incidence of unward reaction from chemotherapy,observation group was significantly lower than control group(P<0.05).Results show that Granule is helpful to relieve the patients’clinical symptoms,reduce their incidence of unward reaction from chemotherapy,and alleviate their sufferings.