奥拉西坦联合尼莫地平治疗脑梗死后血管性痴呆的临床疗效及其安全性

Clinical efficacy and safety of oxiracetam combined with nimodipine in the treatment of vascular dementia after cerebral infarction

目的探讨奥拉西坦联合尼莫地平治疗脑梗死(CI)后血管性痴呆(VD)的临床疗效。方法选取淄博市市级机关医院2017年4月—2019年10月收治的CI后VD患者68例,按照随机数字表法分为对照组与试验组,各34例。对照组予以尼莫地平治疗,试验组在对照组基础上联合奥拉西坦治疗。比较2组临床疗效,用药前后简易智能精神状态评价量表(MMSE)评分、临床痴呆评定量表(CDR)评分、日常生活能力量表(ADL)评分、超氧化物歧化酶(SOD)、血清一氧化碳(NO),并观察2组不良反应发生情况。结果试验组治疗总有效率高于对照组(P<0.05)。用药前2组MMSE评分、CDR评分、ADL评分、SOD、NO比较,差异无统计学意义(P>0.05);用药后试验组MMSE评分、SOD高于对照组,CDR评分、ADL评分、NO低于对照组(P<0.05)。试验组不良反应发生率低于对照组(P<0.05)。结论奥拉西坦联合尼莫地平治疗CI后VD的临床疗效确切,可有效改善患者认知能力,减轻其痴呆症状,提高生活自理能力,且安全性较高。

Objective To investigate the clinical efficacy and safety of oxiracetam combined with nimodipine in the treatment of vascular dementia(VD)after cerebral infarction(CI).Methods A total of 68 cases of patients with VD after CI were selected from April 2017 to October 2019 in Zibo Municipal Government Hospital,which were randomly divided into control group and experimental group,with 34 cases in each group.The control group was treated with nimodipine,the experimental group was treated with oxiracetam on the basis of the control group.Clinical efficacy,MMSE score,CDR score,ADL score,SOD and NO before and after medication were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate of the experimental group was higher than control group(P<0.05).Before medication,there was NO significant difference in MMSE score,CDR score,ADL score,SOD and NO between the two groups(P>0.05);after medication,the experimental group of MMSE score and SOD were higher than control group,while CDR score,ADL score and NO were lower than control group(P<0.05).The incidence of adverse reactions in the experimental group was lower than control group(P<0.05).Conclusion Oxiracetam combined with nimodipine have an exact clinical effect for VD after CI,which can effectively improve the cognitive ability of patients and alleviate the symptoms of dementia,improve self-care ability,and with high safety.