隔姜灸治疗慢性萎缩性胃炎的临床研究

Clinical Study of Ginger-partitioned Moxibustion for Chronic Atrophic Gastritis

目的观察隔姜灸治疗慢性萎缩性胃炎(CAG)的临床疗效及其对血清胃泌素-17(G-17)及胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ(PGⅠ/PGⅡ)的影响。方法收治CAG患者100例,随机分为治疗组与对照组,每组50例。对照组予西医常规治疗,治疗组在对照组基础上加用隔姜灸。观察两组患者的临床疗效,比较中医症状总积分、胃黏膜组织形态学改变及血清G-17、PGⅠ/PGⅡ的变化。结果治疗组总有效率为89.4%,高于对照组的77.1%,差异有统计学意义(P<0.05)。与对照组比较,治疗组可明显减轻胃脘胀满、胃脘疼痛、胸胁疼痛的中医症状(P<0.05),改善胃黏膜萎缩(P<0.05)。治疗组治疗后血清G-17、PGⅠ/PGⅡ的水平均高于对照组(P<0.05)。结论隔姜灸可在药物治疗基础上进一步提高慢性萎缩性胃炎的临床疗效,改善中医症状、胃黏膜萎缩,可能与其上调G-17及PGⅠ/PGⅡ有关。

Objective To observe the clinical efficacy of ginger-partitioned moxibustion in treating chronic atrophic gastritis(CAG)and its effects on serum gastrin-17(G-17)and pepsinogenⅠ/pepsinogenⅡ(PGⅠ/PGⅡ).Method One hundred CAG patients were included and randomized into a treatment group and a control group,with 50 cases in each group.The control group was given conventional Western medicine treatment,while the treatment group was given additional ginger-partitioned moxibustion.Clinical efficacy was observed in each group,and the total score of traditional Chinese medicine(TCM)symptoms,histomorphologic alterations in gastric mucosa and changes in serum G-17 and PGⅠ/PGⅡwere compared.Result The total effective rate was 89.4%in the treatment group,higher than 77.1%in the control group,and the difference was statistically significant(P<0.05).Compared with the control group,the treatment group showed significant reduction in TCM symptoms including gastric bloating and fullness,gastric pain and pain in the chest and hypochondrium(P<0.05),along with improvement in gastric atrophy(P<0.05).After treatment,the levels of serum G-17 and PGⅠ/PGⅡwere higher in the treatment group than in the control group(P<0.05).Conclusion Based on medication,ginger-partitioned moxibustion can further enhance the clinical efficacy in treating CAG,improving TCM symptoms and gastric atrophy,which may be associated with the up-regulation of G-17 and PGⅠ/PGⅡ.