五门十变针法联合天应灸治疗肝郁气滞型乳腺增生临床研究

Clinical Study of Five-door and Ten-variation Acupuncture Plus Tian Ying Moxibustion in Treating Mammary Gland Hyperplasia of Liver Depression and Qi Stagnation Type

目的观察五门十变针法联合天应灸治疗肝郁气滞型乳腺增生的临床疗效及对血清激素水平、局部氧合/脱氧血红蛋白水平的影响。方法纳入98例肝郁气滞型乳腺增生患者并随机分为对照组和观察组,每组49例。对照组予口服三苯氧胺,观察组予五门十变针法联合天应灸治疗,两组均连续治疗8周。观察两组临床症状评分、肝郁气滞证候评分、血清激素水平和局部氧合/脱氧血红蛋白水平的变化情况,比较两组临床疗效。结果治疗后,对照组总有效率为61.2%,低于观察组的91.8%,两组比较差异具有统计学意义(P<0.05)。两组治疗后临床症状评分、肝郁气滞证候评分、血清激素和局部氧合/脱氧血红蛋白水平均优于治疗前(P<0.05),且观察组治疗后上述各项结果均优于对照组(P<0.05)。结论五门十变针法联合天应灸治疗肝郁气滞型乳腺增生疗效优于西药治疗,可减轻乳房疼痛,缩小乳腺增生肿块大小,软化乳腺增生的肿块和改善肝郁气滞证候,并恢复血清激素水平,降低氧合血红蛋白水平,升高脱氧血红蛋白水平。

Objective To investigate the clinical efficacy of five-door and ten-variation acupuncture plus Tian Ying moxibustion for mammary gland hyperplasia of liver depression and qi stagnation type and its effect on serum hormone levels and local oxyhemoglobin/deoxyhemoglobin levels.Method Ninety-eight patients with mammary gland hyperplasia of liver depression and qi stagnation type were enrolled and randomized to a control group and an observation group,with 49 cases in each group.The control group received oral administration of Tamoxifen and the observation group received five-door and ten-variation acupuncture plus Tian Ying moxibustion.Both groups were treated for eight consecutive weeks.The clinical symptom score and the liver depression and qi stagnation syndrome score were recorded and serum hormone levels and local oxyhemoglobin/deoxyhemoglobin levels were measured in the two groups.The clinical therapeutic effects were compared between the two groups.Result After treatment,the clinical total efficacy rate was 61.2%in the control group,which was lower than 91.8%in the observation group with a statistically significant difference between the two groups(P<0.05).After treatment,the clinical symptom score,the liver depression and qi stagnation syndrome score,serum hormone levels and local oxyhemoglobin/deoxyhemoglobin levels were better in the two groups compared with before(P<0.05)and better in the observation group than in the control group(P<0.05).Conclusions Five-door and ten-variation acupuncture plus Tian Ying moxibustion is more effective than Western drug therapy in treating mammary gland hyperplasia of liver depression and qi stagnation type.It can alleviate breast pain,reduce and soften proliferative breast mass,relieve liver depression and qi stagnation syndrome,restore serum hormone levels,decrease oxyhemoglobin levels and increase deoxyhemoglobin levels.