新型血清学指标早期预测急性胰腺炎严重程度及预后的研究进展

Research progress of new serological indicators in early predicting severity and prognosis of acute pancreatitis

急性胰腺炎(AP)作为临床上常见的炎症性疾病,其发展为重症AP后引发的全身炎症反应综合征及多器官功能障碍常常给患者带来巨大经济损失甚至造成死亡。早期评估病情及预测预后并采取干预措施尤为重要。现有的评估病情的标准尚存在复杂性、主观性和低灵敏度的缺陷,因此需要更为简单、快捷、高灵敏度的AP评价指标来早期评估病情和预测预后。近年的研究发现了红细胞分布宽度(RDW)、血小板平均体积(MPV)和抵抗素等血清标志物与AP病情发展及预后具有相关性,本文就该新型血清学指标对于AP病情发展及预后的预测作用进行综述。

As a common inflammatory disease in clinical practice,acute pancreatitis(AP)develops into systemic inflammatory response syndrome and multi-organ dysfunction after severe AP,which often brings huge economic loss and even death to patients.Early assessment of the disease and prognosis and intervention are particularly important. The existing evaluation criteria for evaluating the disease still have defects of complexity,subjectivity and low sensitivity. Therefore,a more convenient and faster AP evaluation index with high sensitivity is needed for early evaluation of disease and prediction of prognosis. In recent years,some studies have suggested that red blood cell distribution width,mean platelet volume and resistin are correlated with the development and prognosis of AP. This paper reviews the predictive effect of this new serological index on the development and prognosis of AP.