用于肾移植术后输尿管狭窄再通的磁吻合器的设计及实验验证

Design and Experimental Verification of Magnamosis Device for Recanalization of Ureteral Stricture After Renal Transplantation

目的设计并加工用于肾移植术后输尿管狭窄再通的磁吻合器,以实验兔为模型验证其可行性。方法分析泌尿系统管腔解剖特点,结合磁吻合技术原理,设计双通路磁体置入路径,提出了中央通孔结构圆柱体和尾挂结构圆柱体的两种类型设计方案,并在实验兔上进行了吻合再通效果验证。结果成功设计并加工出适用于不同狭窄程度下的输尿管狭窄的吻合再通磁体。中央通孔结构圆柱状磁体适用于输尿管严重狭窄,但导丝尚能通过的情况。尾挂结构圆柱状磁体适用于输尿管完全闭塞。以输尿管远端结扎的实验兔为模型,利用上述磁体成功实现了输尿管膀胱磁吻合。结论基于磁吻合技术的用于肾移植术后输尿管狭窄的磁吻合器设计巧妙,易加工,能满足输尿管不同狭窄程度下的吻合再通,具有临床应用前景。

Objective To design and manufacture magnamosis device for recanalization of ureteral stricture after kidney transplantation and verify its feasibility in experimental rabbits.Methods Based on the analysis of the anatomical characteristics of lumen of the urinary system,combined with the principle of magnetic anastomosis technology,a dual-path magnet placement path was designed.Two design schemes of central through-hole cylinder and tail-hanging cylinder were proposed,and the anastomosis recanalization effect was verified on experimental rabbits.Results The anastomosis recanalization magnets for ureteral stricture with different degree of stricture were successfully designed and manufactured.The cylindrical magnet with a central through-hole structure is suitable for severe ureteral stricture,but the guide wire can still pass through.The cylindrical magnet with tail hanging structure is suitable for complete ureteral occlusion.The magnetic anastomosis of ureter and bladder was successfully achieved in rabbits with distal ureteral ligation.Conclusion The magnamosis device based on magnetic anastomosis technology for ureteral stenosis after kidney transplantation is ingenious in design and easy to be processed,which can meet the requirements of anastomotic recanalization of ureteral stenosis in different degrees,and has a prospect of clinical application.