内质网-线粒体接触与抗病毒免疫应答

ER-mitochondria contact and antiviral immune response

内质网和线粒体是人体内参与组织代谢的重要细胞器,研究人员在显微镜下观察到内质网和线粒体之间存在着特殊的物理连接,将之称为内质网-线粒体接触。既往研究表明,内质网-线粒体接触不仅可以调控机体的炎症反应、细胞自噬和磷脂合成等生理过程;还在病毒致病或机体抗病毒免疫应答过程中发挥重要作用。本文主要围绕内质网和线粒体的相互作用、机制及其与机体抗病毒免疫应答这两个方面进行综述,以期对内质网-线粒体接触有更进一步的认识,并为临床治疗病毒感染性疾病提供新的靶点与方向。

Endoplasmic reticulum and mitochondria are important organelles involved in tissue metabolism in the human body. A special physical connection between ER and mitochondria is observed through microscope,which is called ER-mitochondria contact. Studies have shown that ER-mitochondria contact can regulate diverse biological processes such as inflammatory response,autophagy,and phospholipid biosynthesis. In addition,studies on the pathogenic mechanisms of DNA viruses and RNA viruses have found that ER-mitochondria contact also plays an important role in virus pathogenicity or antiviral immune response. In this review,we summarize the current knowledge on ER-mitochondria contact and its roles in antiviral defense,in order to have a better understanding of ER-mitochondria contact and provide new targets and directions for clinical treatment of viral infection.