急性胰腺炎患者血清二胺氧化酶及D-乳酸水平与肠道功能的关系

Relationship between serum diamine oxidase and D-lactic acid levels with intestinal function in patients with acute pancreatitis

目的分析急性胰腺炎(AP)患者二胺氧化酶(DAO)及D-乳酸(D-LA)水平与肠道功能的关系。方法选取2019年1月至2020年3月该院急诊医学科收治的AP住院患者60例,其中轻症34例,中度重症18例,重症8例。另选取健康体检者40例作为对照组。分别比较DAO及D-LA水平,观察患者肠道功能恢复情况。结果AP组血清DAO和D-LA水平明显高于对照组(P<0.01);重症AP患者肠道功能恢复前血清DAO及D-LA水平明显高于中度重症及轻症患者(P<0.05),重症AP患者肠道功能恢复时间长于轻症及中度重症患者,差异均有统计学意义(P<0.05)。结论病情越重的AP患者肠道恢复时间越长,血清DAO与D-LA水平越高,监测血清DAO与D-LA水平有利于判断AP的治疗效果和预后。

Objective To analyze the relationship between the levels of diamine oxidase(DAO)and D-lactic acid(D-LA)with the intestinal function in patients with acute pancreatitis(AP).Methods Sixty inpatients with AP admitted to the emergency department of this hospital from January 2019 to March 2020 were selected,including 34 mild cases,18 moderate cases and 8 severe cases.Other 40 healthy subjects undergoing the healthy physical examination were selected as the control group.The levels of DAO and D-LA were compared respectively,and the recovery situation of intestinal function was observed.Results The levels of serum DAO and D-LA in the AP group were significantly higher than those in the control group(P<0.01).The levels of DAO and D-LA before the intestinal function recovery in the patients with severe AP were significantly higher than those in the moderate-severe patients and mild patients(P<0.05),the recovery time of intestinal function in the patients with severe AP was longer than that in the patients with mild and moderately AP,and the differences were statistically significant(P<0.05).Conclusion The more severe the disease of AP,the longer the intestinal recovery time and the higher the serum DAO and D-LA levels;monitoring serum DAO and D-LA levels is conducive to judge the therapeutic effect and prognosis of AP.