叉头框蛋白A1表达与结直肠癌临床病理特征的相关性研究

Correlation between FOXA1 and Clinicopathological Features of Colorectal Cancer

目的:探究叉头框蛋白A1(FOXA1)表达与结直肠癌临床病理特征的关系及其对生存状况的影响。方法:选取2017年1月—2019年1月在我院行结直肠癌根治术的患者100例,取其癌组织、癌旁组织,用免疫组织化学法检测FOXA1表达情况,分析FOXA1表达与患者临床病理资料的相关性,对患者进行随访,观察FOXA1表达对总生存期(OS)影响。结果:癌组织中FOXA1表达阳性率高于癌旁组织(60.0%vs 32.0%,χ^(2)=15.781,P<0.001)。FOXA1表达阳性组TNMⅢ期、中低分化、淋巴结转移、脉管浸润率高于FOXA1表达阴性组(均P<0.05)。随访16-40个月,中位随访时间27个月,失访7例,成功随访率为93.0%,共死亡13例。生存分析显示FOXA1表达阳性组累积生存率低于FOXA1表达阴性组(P<0.05)。多因素COX分析显示,FOXA1阳性表达、TNM分期为Ⅲ期、淋巴结转移、脉管浸润是结直肠癌OS的独立危险因素(P<0.05)。结论:FOXA1在结直肠癌组织中表达上调,其与较差的临床病理特征有关。FOXA1高表达的结直肠癌患者预后较差,FOXA1与结直肠癌的发展和进程有关。

Objective To investigate the relationship between the expression of F1 framework protein A1(FOXA1)and the clinicopathological characteristics of colorectal cancer and its impact on survival.Methods Ninety patients undergoing radical surgery for colorectal cancer were selected.The expression of FOXA1 was detected by immunohistochemistry in cancer tissues and adjacent tissues.The correlation between FOXA1 expression and clinical pathological data was analyzed.The patients were followed up to observe the expression of FOXA1 and the impact of overall survival(OS).Results The positive rate of FOXA1 expression in cancer tissue was higher than that in adjacent tissues(60.0%vs.32.0%,χ^(2)=15.781,P=0.000).The FOXA1 expression positive group had higher rate of TNM stageⅢ,low and medium differentiation,lymph node metastasis,and vascular invasion than the FOXA1 expression negative group(all P<0.05).The follow-up period was 16-40 months,the median follow-up time was 27 months,7 cases were lost to follow-up,the successful follow-up rate was 93.0%,and a total of 13 deaths.Kaplan-Meier method and Log-rank analysis showed that the cumulative OS rate of FOXA1 positive group was lower than that of FOXA1 negative group(P<0.05).Multivariate COX analysis showed that FOXA1 expression,TNM stage,lymph node metastasis,and vascular invasion were independent factors affecting OS of colorectal cancer(P<0.05).Conclusion FOXA1 is up-regulated in colorectal cancer tissues,which is related to poor clinicopathological characteristics.Colorectal cancer patients with high FOXA1 expression have a poor prognosis,and FOXA1 is related to the development and progression of colorectal cancer.