注射用艾普拉唑钠联合生长抑素对重症急性胰腺炎患者氧化应激指标及急性呼吸窘迫综合征发生率的影响

Effects of Ilaprazole Sodium for Injection Combined with Somatostatin on Oxidative Stress Index and Incidence of ARDS in Patients with Severe Acute Pancreatitis

目的:观察重症急性胰腺炎(SAP)患者经注射用艾普拉唑钠联合注射用生长抑素(SS)疗效,以期为指导SAP患者的合理用药提供参考。方法:选取本院2017年2月~2020年2月收治的SAP患者80例作为研究对象,采用随机数字表法分为对照组和观察组,每组40例。两组均实施常规治疗,在此基础上对照组采用SS治疗,观察组采用注射用艾普拉唑钠联合SS治疗。记录两组治疗期间急性呼吸窘迫综合征(ARDS)不良反应发生及病死情况;分别于治疗前、治疗6天时,检测两组氧化应激指标[血清丙二醛(MDA)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)];记录两组治疗期间不良反应发生情况。结果:观察组ARDS不良反应发生率低于对照组,且有统计学差异(P<0.05);两组病死率比较,无统计学差异(P>0.05);治疗6天后,观察组MDA水平低于对照组,SOD及GSH-Px水平高于对照组,具有统计学差异(P<0.05);两组不良反应发生率比较,无统计学差异(P>0.05)。结论:SAP患者采用注射用艾普拉唑钠联合SS治疗效果较好,患者氧化应激程度减轻,ARDS不良反应发生率降低,且联合用药不良反应未明显增加。

Objective:To observe the therapeutic effects of severe acute pancreatitis(SAP)patients with ilaprazole sodium for injection combined with somatostatin(SS)injection,in order to provide references for guiding rational drug treatment for SAP patients.Methods:A total of 80 patients with SAP treated in our hospital from February 2017 to February 2020 were selected as research subjects.According to the random number table method,they were divided into the control group and the observation group,40 cases in each group.Both groups were treated with conventional treatment.On this basis,the control group was treated with SS,and the observation group was treated with injection of ilaprazole sodium for injection combined with SS.Record the incidence of adverse reactions and death of acute respiratory distress syndrome(ARDS)during the treatment of the two groups;before treatment and 6 days after treatment,the oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)]in both groups were detected;incidence of adverse reactions during treatment in both groups was recorded.Results:The incidence of ARDS in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05);there was no significant difference in the mortality rate between the two groups(P>0.05).After treatment for 6 days,the MDA level in the observation group was lower than that in the control group,and the levels of SOD and GSH-Px were higher than that in the control group,the difference was statistically significant(P<0.05);compared the incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:Ipratazole sodium for injection combined with SS injection has a better benefit in the treatment of SAP patients,and their degree of oxidative stress and the incidence of adverse reaction are reduced.It doesn t increase the adverse reactions of combined medication.