血脂和尿微量白蛋白在糖尿病视网膜病变患者中的表达及与其相关性分析

Expression of blood lipids and u-albumin in patients with diabetic retinitis and its correlation with the disease

目的:分析血脂和尿微量白蛋白(u-albumin,u-ALB)在糖尿病视网膜病变(Diabetic retinitis,DR)患者中的表达及与其相关性。方法:选取2016年3月至2018年4月我院收治的122例糖尿病住院患者作为研究对象的糖尿病组,选取同时期到我院体检的120例健康志愿者作为研究对象的对照组。检测并比较不同人群血脂、u-ALB水平情况,计算糖尿病患者的DR发生率,采用多因素logistic回归分析糖尿病患者发生DR的相关危险因素。结果:糖尿病组总胆固醇(Serum total cholesterol,TC)、低密度脂蛋白胆固醇(Low-Density Lipoprotein Cholesterol,LDL-C)、高密度脂蛋白胆固醇(Hight-Density Lipoprotein Cholesterol,HDL-C)、甘油三酯(Triglyceride,TG)、2小时空腹血糖(2 hours postprandial blood glucose,2 h FPG)、u-ALB水平均明显高于对照组(P<0.05);122例糖尿病患者中38例患者发生DR,DR发生率31.14%。DR组、非DR组患者年龄、病程、糖尿病家族史、收缩压(Systolic Blood Pressure,SBP)、舒张压(Diastolic blood pressure,DBP)、TC、LDL-C、HDL-C、TG、2 h FPG、u-ALB水平比较存在明显差异(P<0.05),DR组患者年龄、病程、糖尿病家族史、SBP、DBP、TC、HDL-C、TG、LDL-C、2hFPG、u-ALB水平明显高于非DR组(P<0.05);logistic回归分析结果显示,病程、糖尿病家族史、SBP、DBP、TC、LDL-C、HDL-C、TG、2 h FPG、u-ALB水平是糖尿病患者发生DR的独立危险因素(P<0.05)。结论:DR患者血脂、u-ALB水平较高,血脂、u-ALB水平是影响糖尿病患者发生DR的独立危险因素。

Objective:To analyze the expression of blood lipids and u-albumin(u-ALB)in patients with diabetic retinitis(DR)and its correlation with the disease.Methods:The clinical data of 122 in patients with diabetes who were admitted to this hospital from March 2016 to April 2018 were selected as the diabetes group in this study,and 120 healthy volunteers who came to this hospital for physical examination during the same period were selected as the control group.The blood lipids and u-ALB expressions in different people were tested and compared,the incidence of DR in diabetic patients was calculated,and multivariate logistic regression was used to analyze the related risk factors affecting the occurrence of DR in patient with diabetes.Results:The serum total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TTG),2 hours postprandial blood glucose(2h FPG),and u-ALB levels in the diabetes group were significantly higher than those in the control group(P<0.05).Among 122 diabetic patients,38 patients had DR,and the incidence of DR was 31.14%.There were significant differences in age,course of disease,family history of diabetes,systolic blood pressure(SBP),diastolic blood pressure(DBP),TC,LDL-C,HDL-C,TG,2hFPG and u-ALB levels of patients between the DR group and the non-DR group(P<0.05).The age,course of disease,family history of diabetes,SBP,DBP,TC,HDL-C,TG,LDL-C,2hFPG,u-ALB levels of patients in the DR group were significantly higher than those in the non-DR group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that the course of disease,family history of diabetes,SBP,DBP,TC,LDL-C,HDL-C,TG,2hFPG,u-ALB levels were independent risk factors affecting the occurrence of DR in patient with diabetes(P<0.05).Conclusion:DR patients have higher levels of blood lipids and u-ALB,and blood lipids and u-ALB levels are independent risk factors affecting occurrence of DR in patient with diabetes.