玻璃体腔药物注射治疗非动脉炎性前部缺血性视神经病变研究进展

Research progress of intravitreal injections for nonarteritic anterior ischemic optic neuropathy

非动脉炎性前部缺血性视神经病变(NAION)是常见的中老年急性视神经病变,以视盘水肿伴视野缺损为主要特征。目前NAION尚无标准治疗方案,治疗重点在于控制全身疾病及其他危险因素、减轻视盘水肿、营养神经、改善微循环等。近年来,玻璃体腔药物注射作为新的治疗手段应用于NAION治疗,其能使药物快速到达眼内靶组织,并维持较高浓度,增加疗效的同时不引起严重的全身并发症。本文主要对玻璃体腔注射抗血管内皮细胞生长因子、曲安奈德、促红细胞生成素等治疗NAION的研究进展进行综述。

Nonarteritic anterior ischemic optic neuropathy(NAION)is a common type of acute optic neuropathy in elderly,characterized by optic disc edema and visual field defect.At present,there is no generally accepted treatment,and the treatment of NAION is to control systemic disease and other risk factors,reduce optic disc edema,nurture nerve and improve microcirculation.In recent years,intravitreal drug injection has been used as a new therapy of NAION.It can make drug reach the target issue in the eye rapidly and maintain a relatively high concentration,which can enhance the efficacy without causing severe systemic complication.In this article,the effect of intravitreal injection of anti-vascular endothelial growth factor,triamcinolone acetonide,and erythropoietin in NAION was reviewed.