特发性黄斑前膜治疗的相关研究

Advances in the treatment of idiopathic macular epiretinal membrane

特发性黄斑前膜(iERM)是一种发生在玻璃体视网膜界面的纤维细胞增生性疾病,其发生和发展与老化显著相关。目前,iERM处理方法的选择比较局限,主要是临床观察或随访和玻璃体切割手术疗法。iERM患者黄斑区受到不可逆损伤的时间点尚无法准确评估,所以无法预测早期iERM症状轻微时进行手术治疗的安全性以及是否应当在患者发生视物变形和视力下降时再进行手术治疗。iERM的形成是视网膜表面纤维化的过程,目前关于组织纤维化相关的研究已受到关注,这些研究结果将有助于探讨iERM治疗的新方法,同时也为iERM形成的原因和发病机制研究提供了新的线索。本文对iERM的研究及治疗进展进行了总结。

Idiopathic epiretinal membrane(iERM)is one of common fibroblast proliferative diseases in vitreoretinal interface and is significantly associated with aging.The treatment and management methods of iERM are limited,primarily including clinical following-up and vitrectomy.The time point of irreversible functional and structural damage of retina in macula is difficult to identify.Therefore,we can not predict whether surgery is safe when the symptoms of early iERM are mild,or whether surgical treatment should be postponed until metamorphopsia and vision loss occur.The formation of iERM is a process of retinal surface fibrosis,and fibrosis is a very common process in human body.Many studies on fibrosis have got a growing concern,which is helpful for us to find new treatment approch and also provides more clues of the causes of iERM.The research progress in the treatment of iERM was reviewed.