促炎症消退介质与眼部疾病

Specialized proresolving lipid mediators and eye diseases

促炎症消退介质(SPMs)是一类新型的内源性炎症调控介质,包括脂氧素、消退素、保护素和巨噬细胞源性消退素家族。目前研究发现,SPMs为机体自身合成物质,可以促进炎症消退、清除病原体、恢复机体内环境稳定,并有抑制细胞凋亡、促进创伤愈合和神经保护等功能,对角膜炎症、干眼、葡萄膜炎、视网膜脉络膜新生血管性疾病等均有一定的治疗作用。本文就SPMs家族各类分子在多种眼科疾病发生和发展中的作用机制研究进行综述,以期为新型眼科药物的研发提供思路。

Novel endogenous lipid-mediated molecules including lipoxins,resolvins,protectins,and maresin families are discovered recently and are collectively called specialized proresolving lipid mediators(SPMs).SPMs have the potential to promote the resolution of inflammation,the elimination of pathogen,and the restoration of homeostasis.Meanwhile,SPMs also have the function of apoptosis inhibition,wound healing,and neuroprotection.SPMs play an important role in the treatment of many eye diseases,such as corneal inflammatory diseases,dry eye,uveitis,retinal and choroidal neovascularization diseases,etc.In this article,the mechanisms involving the role of SPMs in the occurrence and progress of eye diseases were reviewed to provide a general new basis for the future development of new ophthalmic drugs.