Viperin介导细胞抗病毒效应研究进展

Progress on the Cellular Antiviral Effect by Viperin Protein

先天性免疫是宿主抵抗外来病原入侵的第一道防线,是免疫系统的重要组成成分。Viperin是受干扰素(interferon,IFN)等多种因素诱导的抗病毒蛋白。Viperin可以通过介导信号转导、控制细胞代谢、调控IFN水平等多种途径来抑制DNA病毒、RNA病毒以及细菌等多种病原微生物的增殖,同时参与调节温度并影响巨噬细胞的极化及细胞因子的分泌等。由于Viperin是一种新近发现的信号蛋白,其具体的抗病毒机制尚未明确。近年来随着分子生物学技术的发展,对该蛋白的研究引起了广泛关注并取得了较大进展。本文仅就Viperin的结构功能、抗病毒机制、调控机制等几个方面进行阐述,为Viperin的深入研究提供参考。

Innate immunity is the first line of host resistance to microbial invasion and a critical component of the immune system.Viperin is an innate immune-mediated protein with antiviral activity and induced by many factors such as interferons.It can suppress the replication of DNA viruses,RNA viruses and even some bacteria and other pathogenic microorganisms by a variety of ways including regulation of cell metabolism,interferon expression and cell signaling.Viperin also plays a role as a regulator in thermogenesis,polarization of macrophages and secretion of cytokines.However,the specific antiviral mechanism of Viperin is not yet defined well since it is a kind of new signal molecule of innate immunity system.In recent years,Viperin protein has increasingly attracted many attentions and related studies with the development of molecular biology techniques.In this paper,several major aspects of Viperin,such as its structure,function,antiviral mechanism and regulatory role were systemically reviewed,providing a reference for the further research.