探讨微创治疗甲状腺癌的疗效及对创伤应激指标的影响

Discussion on the effect of minimally invasive treatment of thyroid cancer and its impact on posttraumatic stress indicators

目的探讨微创治疗甲状腺癌的疗效及对创伤应激指标的影响。方法100例甲状腺癌患者作为观察对象,依据治疗方案的不同分为对照组和实验组,各50例。对照组采用常规开放手术治疗,实验组采用微创手术治疗。比较两组患者的手术相关指标(手术时间、术后引流量、住院时间、清除淋巴结数量),治疗前后的血清创伤应激指标[白细胞介素-6(IL-6)、皮质醇(CORT)]。结果实验组患者的手术时间(44.2±10.2)min、住院时间(5.2±1.2)d短于对照组的(72.3±14.4)min、(7.7±1.3)d,术后引流量(77.3±4.3)ml少于对照组的(80.2±5.4)ml,差异具有统计学意义(P<0.05);两组患者的清除淋巴结数量比较,差异无统计学意义(P>0.05)。治疗前,两组患者的IL-6、CORT水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的IL-6、CORT水平均高于本组治疗前,但实验组患者的IL-6(5.2±1.1)mmol/L、CORT(315.3±25.3)mmol/L低于对照组的(7.8±2.1)、(433.5±27.4)mmol/L,差异具有统计学意义(P<0.05)。结论甲状腺癌患者接受微创手术治疗,能够取得较为理想的效果,减轻创伤应激反应,改善患者预后情况。

Objective To discuss the efficacy of minimally invasive treatment of thyroid cancer and its impact on post-traumatic stress indicators.Methods A total of 100 patients with thyroid cancer as observation subjects were divided into control group and experimental group according to different regimens,with 50 cases in each group.The control group was treated with conventional open surgery,and the experimental group was treated with minimally invasive surgery.The surgical related indicators(surgery time,postoperative drainage volume,hospitalization time,number of lymph node dissection),serum post-traumatic stress indicators[interleukin-6(IL-6),cortisol(CORT)]before and after treatment were compared between the two groups.Results The surgery time(44.2±10.2)min and hospitalization time(5.2±1.2)d of the experimental group were shorter than(72.3±14.4)min and(7.7±1.3)d of the control group,and postoperative drainage volume(77.3±4.3)ml was less than(80.2±5.4)ml of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in number of lymph node dissection between the two groups(P>0.05).Before treatment,there was no statistically significant difference in levels of IL-6 and CORT between the two groups(P>0.05).After treatment,the levels of IL-6 and CORT of the two groups were higher than those before treatment,but the IL-6(5.2±1.1)mmol/L and CORT(315.3±25.3)mmol/L of the experimental group were lower than(7.8±2.1)and(433.5±27.4)mmol/l of the control group.All the difference was statistically significant(P<0.05).Conclusion Minimally invasive surgery has ideal effect on patients with thyroid cancer,and reduce the posttraumatic stress response,and improve the prognosis of patients.