浅低温冷冻治疗寻常型银屑病的临床疗效探讨

Study on the clinical effect of superficial hypothermic cryotherapy in the treatment of psoriasis vulgaris

目的探讨浅低温冷冻治疗寻常型银屑病的临床疗效。方法34例寻常型银屑病患者,随机分为对照组和研究组,各17例。对照组应用消银颗粒治疗,研究组应用浅低温冷冻治疗。对比两组患者治疗前后的血管内皮生长因子(VEGF)和巨噬细胞移动抑制因子(MIF)水平、银屑病皮损面积及严重程度指数(PASI)评分及治疗效果。结果治疗后,研究组PASI评分(14.8±3.2)分低于对照组的(19.7±4.6)分,差异有统计学意义(P<0.05)。研究组治疗总有效率94.1%高于对照组的64.7%,差异有统计学意义(P<0.05)。治疗后,两组MIF、VEGF水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论应用浅低温冷冻治疗寻常型银屑病效果理想,可以降低患者的皮损程度、MIF和VEGF水平,提高治疗效果,值得临床中广泛推广和应用。

Objective To discuss the clinical efficacy of superficial hypothermic cryotherapy in the treatment of psoriasis vulgaris.Methods A total of 34 patients with psoriasis vulgaris were randomly divided into control group and research group,with 17 cases in each group.The control group was treated with Xiaoyin Granule,and the research group was treated with superficial hypothermic cryotherapy.The vascular endothelial growth factor(VEGF)and macrophage migration inhibitory factor(MIF)levels,psoriasis area and severity index(PASI)score before and after treatment,and therapeutic effect were compared between the two groups.Results After treatment,the PASI score(14.8±3.2)points of the research group was lower than(19.7±4.6)points of the control group,and the difference was statistically significant(P<0.05).The total effective rate 94.1% of the research group was higher than 64.7% of the control group,and the difference was statistically significant(P<0.05).After treatment,the MIF and VEGF of the two groups were lower than those before treatment,and the research group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion Superficial hypothermic cryotherapy has ideal effect on psoriasis vulgaris,and it can reduce the degree of skin lesions,MIF and VEGF levels,and improve the therapeutic effect,which is worthy of clinical promotion and application.