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曲美他嗪联合心脑康胶囊对冠心病稳定型心绞痛患者血清细胞因子水平的影响 被引量:4

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摘要 目的探究曲美他嗪联合心脑康胶囊对冠心病稳定型心绞痛患者血清细胞因子水平的影响。方法选取80例冠心病稳定型心绞痛患者作为研究对象,按随机数字表法分为联合组及对照组,各40例。两组患者均行常规治疗,对照组给予曲美他嗪治疗,联合组在对照组基础上给予心脑康胶囊胶囊治疗。比较两组患者治疗效果、血清细胞因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平、颈动脉斑块情况[斑块厚度(PT)、斑块数量(PN)]及不良发应发生情况。结果联合组患者治疗总有效率95.00%优于对照组的77.50%,差异具有统计学意义(P<0.05)。治疗1个月后,两组患者的CRP、IL-6水平均较治疗前降低,且联合组CRP、IL-6水平均低于对照组,差异具有统计学意义(P<0.05)。治疗1个月后,两组患者的PT、PN水平均较治疗前降低,且联合组PT、PN水平均低于对照组,差异具有统计学意义(P<0.05)。两组患者不良发应发生率比较差异无统计学意义(P>0.05)。结论曲美他嗪联合心脑康胶囊对冠心病稳定型心绞痛患者有良好的治疗效果,可对患者体内血清因子产生抑制作用,改善患者体内斑块情况。
作者 盛凌超
出处 《中国现代药物应用》 2021年第15期194-196,共3页 Chinese Journal of Modern Drug Application
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