慢性阻塞性肺疾病患者气道内分泌性白细胞蛋白酶抑制物表达水平及与肺功能的相关性

Association between expression of secretory leukocyte proteinase inhibitor in airway and lung function in patients with COPD

目的探索慢性阻塞性肺疾病(COPD)患者稳定期与急性加重期气道内SLPI表达水平差异,明确COPD患者肺功能与气道内SLPI表达水平相关性。方法纳入40例COPD患者及40例健康成人为研究对象,检测健康成人痰液中的SLPI浓度及COPD患者稳定期和急性加重期痰液中的SLPI浓度和肺功能(FEV1%pred,FEV1/FVC),比较COPD患者气道内SLPI水平与健康成人差异及稳定期与急性加重期差异,并分析SLPI表达水平与肺功能相关性。结果稳定期COPD患者与健康志愿者气道内SLPI表达水平差异无统计学意义[(46.74±2.30)μg/L vs.(47.60±2.50)μg/L,t=1.321,P=0.190]。COPD患者急性加重期较稳定期气道内SLPI水平明显降低[(38.148±3.59)μg/L vs.(46.74±2.30)μg/L,t=35.707,P=0.01]。COPD患者稳定期气道内SLPI表达水平与FEV1/FVC没有明显相关性(r=0.215,P=0.183),但与FEV1呈正相关(r=0.466,P=0.002);COPD患者急性加重期气道内SLPI表达水平与FEV1/FVC没有明显相关性(r=0.088,P=0.589),但与FEV1%Pred呈正相关(r=0.369,P=0.019)。结论COPD患者急性加重期较稳定期气道内SLPI水平明显降低,气道内SLPI表水平与FEV1%Pred呈正相关。

Objective To explore the difference of secretory leukocyte proteinase inhibitor(SLPI)expression in airway between stable and acute exacerbation chronic obstructive pulmonary disease(COPD)patients,and to clarify the correlation between pulmonary function and the expression of SLPI in airway.Methods A total of 40 COPD patients and 40 healthy adults were included as the objects.SLPI concentration in the sputum of healthy adults and COPD patients and lung function were measured.The difference of SLPI level between COPD patients and healthy adults,and between stable and acute exacerbation COPD was compared.The correlation between SLPI expression and lung function was analyzed.Results There was no significant difference in the expression of SLPI in airway between COPD patients and healthy adults[(46.74±2.30)μg/L(47.60±2.50)μg/L,t=1.321,P=0.190].The level of SLPI in acute exacerbation COPD patients was significantly lower than that in stable COPD patients[(38.15±3.59)μg/Lvs.(46.74±2.30)μg/L,t=35.707,P=0.01].There was no significant correlation between SLPI and FEV1/FVC(r=0.215,P=0.183),but SLPI was positively correlated with FEV1%Pred(r=0.466,P=0.002)in stable C.OPD patients.There was no significant correlation between SLPI and FEV1/FVC(r=0.088,P=0.589),but SLPI was positively correlated with FEV 1%Pred(r=0.369,P=0.019)in acute exacerbation COPD patients.Conclusions SLPI in airway of acute exacerbation COPD patients was significantly lower than that of stable COPD patients.SLPI in airway is positively correlated with FEV1%Pred in COPD patients.