麝香保心丸对X综合征患者外周血内皮微粒含量的影响

Effect of Shexiang Baoxin Pills on endothelial microparticles content in peripheral blood of patients with syndrome X

目的探讨麝香保心丸对X综合征患者外周血内皮微粒(EMPs)含量的影响。方法选取确诊为X综合征的患者75例,抽取外周血检测EMPs含量,并与健康人群进行比较。将75例患者随机分为2组,对照组给予硝酸酯类、β受体阻滞剂等西药治疗,研究组给予麝香保心丸治疗。比较2组患者治疗前后EMPs含量、西雅图心绞痛量表评分、不良反应发生情况。结果本研究75例患者外周血中EMPs含量为(2.01±0.71)%,高于71例健康人[(0.50±0.34)%],差异有统计学意义(P<0.05)。治疗后,研究组EMPs含量低于治疗前及对照组,差异有统计学意义(P<0.05)。治疗后,研究组西雅图心绞痛量表评分高于治疗前及对照组,差异有统计学意义(P<0.05)。2组不良反应患者发生率比较,差异无统计学意义(P>0.05)。结论麝香保心丸能有效降低X综合征患者外周血中EMPs含量,对血管内皮功能发挥正向调节作用,缓解患者相关症状,且不良反应较少。

Objective To explore the effect of Shexiang Baoxin Pills on endothelial microparticles(EMPs)content in peripheral blood of patients with syndrome X.Methods Totally 75 patients diagnosed as syndrome X were selected and content of EMPs in peripheral blood was detected after blood collection,and the content of EMPs was compared with healthy people.They were randomly divided into two groups,control group was treated with western medicines such as nitrates andβreceptor blockers,while the study group was treated with Shexiang Baoxin Pills.The content of EMPs before and after treatment,the score of Seattle Angina Questionnaire and the incidence of adverse reactions were compared between the two groups.Results The content of EMPs in peripheral blood of 75 patients in this study was(2.01±0.71)%,which was significantly higher than(0.50±0.34)%in the 71 healthy people(P<0.05).After treatment,the EMPs content in the study group decreased significantly,and was also significantly lower than that in the control group(P<0.05).After treatment,the score of Seattle Angina Questionnaire increased significantly in the study group,and was also significantly higher than that in the control group(P<0.05).There was no significant difference in the ratio of patients with adverse reactions between the two groups(P>0.05).Conclusion Shexiang Baoxin Pills can effectively reduce the content of EMPs in the peripheral blood of patients with syndrome X,positively regulate vascular endothelial function,relieve the related symptoms of patients,and cause less adverse reactions.