FOS样抗原1在恶性肿瘤中的研究进展

Research progress of FOS like antigen 1 in malignant tumors

FOS样抗原1(FOSL1)是一种可以在人体内编码FOSL1蛋白的基因,又称为FOS相关抗原1(Fos-related antigen1,FRA1),是活性蛋白1复合物(AP-1)的组成部分,其编码的蛋白受多种信号通路调控,影响肿瘤的增殖、分化、侵袭和转移等多种生物学功能。已有研究证实,FOSL1参与了乳腺癌、结直肠癌、脑胶质瘤、宫颈癌等多种恶性肿瘤的恶性进展。

FOS-like antigen 1(FOSL1)is a gene that can encode FOSL1 protein in human body,also known as FOS related antigen 1(FRA1).It is a component of active protein-1 complex(AP-1).The protein encoded by FOSL1 is regulated by a variety of signal pathways,affecting the proliferation,differentiation,invasion and metastasis of tumor and other biological functions.It has been confirmed that FOSL1 is involved in the malignant progress of breast cancer,colorectal cancer,glioma,cervical cancer and other malignant tumors.This article mainly reviews the regulation of FO-SL1 and its biological role in the proliferation and metastasis of various tumors.