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不同性别和周龄的SD大鼠凝血背景数据的建立

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摘要 不同周龄大鼠血液指标的背景数据测定是每个实验室必备检测之项目,本研究室对4周、6周、13周、17周SD大鼠进行凝血指标的检测,建立本研究室的数据背景资料,为研究不同周龄大鼠的毒理性作用提供参考。方法:选用160只健康SD大鼠,平均分成4组,每组40只,雌雄各半。在4周、6周、13周、17周分别进行眼底静脉丛采血,采血后立即进行离心并检测。结果:经过数据统计分析,得出不同性别周龄的SD大鼠各项血凝指标的均值、标准差、最大值、最小值、变异系数。结论:初步建立了不同性别和年龄的SD大鼠凝血背景数据的建立。
出处 《兽医导刊》 2021年第16期225-226,共2页 Veterinary Orientation
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  • 1HURTT ME,ENGEL S. An update of juvenile animal studies inthe European Union: What do the numbers say? [J]. ReprodToxicol,2015,56: 105 - 108.
  • 2SOELLNER L,OLEJNICZAK K. The need for juvenile animalstudies-A critical review[J]. Regul Toxicol Pharmacol,2013,65( 1) : 87 - 99.
  • 3U. S. Food and Drug Administration,Center for Drug Evaluationand Research,Guidance for industry: nonclinical safety evalua-tion of pediatric drug products[S]. U. S. Department of Healthand Human Services 2006.
  • 4FDA. Center for Drug Evaluation and Research. Guidance for In-dustry: Nonclinical Safety Evaluation of Pediatric Drug Products[EB/OL]. U. S. Department of Health and Human Services,Rockville,MD. ( 2006 - 02) [2014 - 12 - 11]. http:// www. fda.gov/ downloads/ drugs/ guidancecomplianceregulatoryinformation/guidances/ ucm079247. pdf.
  • 5European Medicines Agency ( EMA) ,Committee for Human Me-dicinal Products ( CHMP) . Guideline on the Need for Non-clini-cal Testing in Juvenile Animals on Human Pharmaceuticals forPediatric Indications. January[EB/ OL]. ( 2008 - 01) [2015 -12 - 18]. http:// www. ema. europa. eu/ docs/ en_GB/ document_library/ Scientific_guideline/2009/09/ C500003305. pdf.
  • 6European Medicines Agency. ICH M3 ( R2) : Non-Clinical Safe-ty Studies for the Conduct of Human Clinical Trials and MarketingAuthorization for Pharmaceutica[EB/ OL]. ( 2008 - 06 ) . ht-tp:// www. ema. europa. eu/ docs/ en _GB/ document _library/ Sci-entific_guideline/2009/09/ WC500002941. pdf.
  • 7Guideline ICH Harmonised Tripartite. Guidance on nonclinicalsafety studies for the conduct of human clinical trials and market-ing authorization for pharmaceuticals M3 ( R2) [C/ OL]. Interna-tional Conference on Harmonisation of Echnical Requirements forRegistration of Pharmaceuticals for Human Use. ( 2009 - 06 -11) . http:// www. ich. org/ fileadmin/ Public_Web_Site/ CH_ProdM3_R2_Guideline. pdf.
  • 8ROMIJN HJ,HOFMAN MA,GRAMSBERGEN A. At what ageis the developing cerebral cortex of the rat comparable to that ofthe full-term newborn human baby? [J]. Early Hum Dev,1991,26( 1) : 61 - 67.
  • 9WATSON RE,DESESSO JM,HURTT ME,et al. Postnatalgrowth and morphological development of the brain: a speciescomparison[J]. Birth Defects Res B Dev Reprod Toxicol,2006,77( 5) : 471 - 484.
  • 10DE SCHAEPDRIJVER LM,BAILEY GP,COOGAN TP,et al.Juvenile animal toxicity assessments: decision strategies and stud-y design[M]. Pediatric Drug Development: Concepts and Appli-cations,2013: 201 - 221.

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