基于CiteSpace软件的狼疮性肾炎相关文献的可视化分析

Visualized analysis in related literatures of lupus nephritis based on CiteSpace software

目的基于CiteSpace软件对狼疮性肾炎相关文献进行可视化图谱分析。方法以“lupus nephritis”为主题,检索Web of Science核心数据库相关文献,检索时间设置为2011年1月1日—2020年12月31日,应用CiteSpace软件对相关主题如作者、机构、国家、期刊等进行分析。结果共收集5397篇文献,发文量呈逐年上升的趋势;发文期刊多为风湿、免疫及药理类专刊,发文量前10的期刊平均影响因子为3分;CHAIM PUTTERMAN及CHANDRA MOHAN是狼疮性肾炎发文量最多的作者,分别发表41篇;WEENING J J成为最有影响力的作者,共被引1007次;文献多来自美国和中国,发文量分别为1005、985篇;文献被引次数前6位分别为241、193、166、156、136、129次,研究方向集中在诊断与治疗、专家共识及药物临床效果比较;关键词词频突现前5位分别为长期治疗、静滴环磷酰胺、硫唑嘌呤、补体及维持治疗。预测该领域的前沿热点是关于基础病理研究及药物临床效果的研究。结论狼疮性肾炎领域总体研究已趋于完善。中国与外国的研究合作关系欠紧密,应进一步深入研究狼疮性肾炎的分子机制,并不断开展临床实验和动物实验,从而逐步完善该领域的研究体系。

Objective To perform a visualized analysis in related literatures of lupus nephritis(LN)based on CiteSpace software.Methods Based on the theme of“lupus nephritis”,the related literatures in core database of Web of Science were searched from January 1,2011 to December 31,2020.CiteSpace software was used to analyze the related topics such as authors,institutions,countries and journals.Results A total of 5397 literatures were collected,and the number of published papers showed an increasing trend year by year.The most papers were published in journals involving rheumatology,immunology and pharmacology,and the average impact factor of the top 10 published journals was 3 points.CHAIM PUTTERMAN and CHANDRA MOHAN were the author with the most published articles on LN(41 articles),and WEENING J J was the most influential author with 1007 cited documents.The most of the literatures were from the United States and China,with 1005 and 915 papers respectively.The numbers of the top 6 cited references were 241,193,166,156,136 and 129 times respectively,and the research topics focused on diagnosis and treatment,expert consensus and effect comparison between clinical drugs.The top 5 frequencies of keywords were long-term treatment,intravenous infusion of cyclophosphamide,azathioprine,complement and maintenance therapy.Prediction of the frontier hot spots in this field was about the basic pathological research and the clinical effect of drugs.Conclusion Overall research in the field of lupus nephritis has been improved.The research cooperation between China and foreign countries is not close,so we should further study its molecular mechanism,and continue to carry out clinical and animal experiments,so as to gradually improve the research system in this field.