肠道菌群失调与慢性肾脏疾病相互作用的研究进展

Research progress on interaction between intestinal flora dysregulation and chronic kidney disease

慢性肾疾病(CKD)主要表现为进行性肾小球、肾小管和间质的损害以及肾功能的进行性降低,同时多伴有高血压、促红细胞生成素合成减少和代谢性酸中毒等并发症。肠道菌群失调可能与CKD具有相关性:一方面,肠道微生物区系能够通过炎症、内分泌及神经通路影响CKD的发生和发展过程;另一方面,CKD也可显著改变肠道微生物区系组成和功能,并导致肠道菌群失调。这种相互作用表明肠道菌群失调可能是CKD潜在的治疗靶点。本研究对肠道菌群失调与CKD的相互作用关系以及恢复肠-肾轴功能的治疗方法进行综述。

Chronic kidney disease(CKD)is characterized by progressive glomerular,tubular and interstitial damages,and progressive decline of renal function,often accompanying by complications such as hypertension,reduced erythropoietin synthesis and metabolic acidosis.The imbalance of intestinal flora may be related to CKD.On the one hand,intestinal microflora can affect the occurrence and development of CKD through inflammatory,endocrine and neural pathways;on the other hand,CKD can also significantly change the composition and function of intestinal microflora,and lead to intestinal flora imbalance.This interaction suggests that dysregulation of intestinal flora may be a potential therapeutic target for CKD.In this study,we reviewed the interaction between intestinal flora dysregulation and CKD as well as the treatment methods to restore the function of intestinal renal axis.