高密度脂蛋白胆固醇水平与甲状腺自身免疫状况的相关性研究

Relationship between high density lipoprotein cholesterol level and thyroid autoimmunity

目的探讨中老年人群血清甲状腺球蛋白抗体(TgAb)及甲状腺过氧化物酶抗体(TPOAb)与高密度脂蛋白胆固醇(HDL-C)水平的相关性。方法纳入1348名社区人员作为研究对象,根据HDL-C水平的不同将其分为<1.26 mmol/L组、1.26~<1.53 mmol/L组和≥1.53 mmol/L组,分析3组基线特征、TgAb阳性率、TPOAb阳性率以及影响社区人群甲状腺自身抗体阳性率的因素。结果3组受检者的年龄、舒张压(DBP)比较,差异有统计学意义(P<0.05),其余基线特征以及TgAb、TPOAb阳性率比较,差异无统计学意义(P>0.05)。抗体高滴度者与抗体正常滴度者的HDL-C水平比较,差异无统计学意义(P=0.942),不同促甲状腺激素(TSH)水平组桥本甲状腺炎(HT)患者的HDL-C水平比较,差异无统计学意义(P=0.395)。Logistic回归分析结果显示,HDL-C水平不是甲状腺自身抗体阳性率的影响因素(P>0.05)。结论中老年人群HDL-C水平与部分甲状腺自身抗体(TgAb、TPOAb)的阳性率无显著相关性,HDL-C的免疫调节作用在HT发生机制中的作用可能有限。

Objective To investigate the correlations between serum thyroglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb) and high density lipoprotein cholesterol(HDL-C) level in middle-aged and elderly population. Methods Totally 1 348 community individuals were selected and were divided into<1.26 mmol/L group, 1.26 to<1.53 mmol/L group and≥1.53 mmol/L group according to their levels of HDL-C. The baseline characteristics together with positive rates of TgAb and TPOAb of three groups as well as the factors affecting the positive rates of thyroid autoantibodies were analyzed. Results The age and diastolic blood pressure(DBP) in three groups showed statistically significant difference(P<0.05), while there were no significant differences in other baseline characteristics, as well as the positive rates of TgAb and TPOAb(P>0.05). There were no significant differences in HDL-C levels between high antibody titer population and normal antibody titer ones(P=0.942), and HDL-C levels of Hashimoto’s thyroiditis(HT) patients in differed thyroid stimulating hormone(TSH) group showed no significant differences(P=0.395). Logistic regression analysis showed that HDL-C level was not influencing factor on the positive rates of thyroid autoantibodies(P>0.05). Conclusion Serum HDL-C levels in the middle-aged and elderly population are not associated with the positive rates of some thyroid autoantibodies(TgAb, TPOAb). The immunomodulatory effect of HDL-C may be limited in the mechanism of HT.