通过环加成反应和串联反应构建桥环化合物的研究进展

Recent Advances in the Construction of Bridged Rings through Cycloadditions and Cascade Reactions

桥环化合物广泛存在于天然产物和具有重要生理活性的分子中,在药物化学、天然产物化学、合成化学、材料化学及生命科学等领域具有重要的应用价值.近年来,经过广大化学工作者的不懈努力,已发展了系列高效构建桥环化合物的新方法.从环加成反应和串联反应两种策略出发,详细介绍近五年来用于构建桥环化合物的方法及最新研究进展,简要分析目前方法的优势及存在的问题,以期为从事有机合成及相关领域的研究者提供有益借鉴和参考.

Bridged rings are frequently encountered in natural products and biologically active molecules,which have signif-icant application in the field of medicinal chemistry,natural product chemistry,synthetic chemistry,material chemistry and life science.In recent years,with the unremitting efforts of a large number of chemists,a series of new methods have been devel-oped for the efficient synthesis of bridged compounds.The detailed synthetic methods to access bridged compounds in the past five years involving cycloadditions and cascade reactions are summarized,and the advantages and problems of the current methods are briefly analyzed,which would provide useful reference for the researchers engaged in organic synthesis and re-lated fields.