亚铁离子荧光探针的研究进展

Recent Progress in Fluorescent Probes for the Detection of Ferrous Ion

铁作为生命系统中最丰富的过渡金属元素,在许多生理和病理过程中发挥着无可替代的作用.铁平衡失调不仅会导致诸如癌症、心血管疾病、神经退行性疾病等的发生和发展,而且还会造成细胞铁死亡.尽管细胞中的铁有Fe^(2+)和Fe~(3+)两种形式,但细胞还原性微环境使其主要以Fe^(2+)形式存在.因此,开发一种对Fe^(2+)的特异性检测技术有助于深入了解Fe^(2+)与人类健康和疾病的关系.随着荧光成像技术的发展,近年来特异性检测Fe^(2+)的荧光探针引起学者们的极大关注.对近10年来报道的Fe^(2+)荧光探针,根据探针的设计思路、与Fe^(2+)的作用机理、光学特性以及其生物应用等方面进行了总结,并对Fe^(2+)荧光探针的发展前景进行了展望.

Irons,as the most abundant transition metal in living system,play an irreplaceable role in many physiological and pathological processes.The misregulation of Fe^(2+)homeostasis not only affects the occurence and delelopment of various diseases,such as cancer,cardiovascular disease and neurodegenerative disorders,but also induces ferroptosis.Although two forms of iron(Fe^(2+)and Fe3+)exist in cells,reducing microenvironment of cells makes it exist mainly in the form of Fe^(2+).Therefore,developing a sensitive approach for Fe^(2+)is particularly important because it may contribute to the in-depth understanding of the relationship between Fe^(2+)and human health and disease.In recent years,with the rapid development of fluorescent imaging technique,fluorescent probes for the sensitive detection of Fe^(2+)have attracted great interest.Fe^(2+)fluorescent probes reported in the last ten years are summarized,according to probes design,sensing mechanisms with Fe^(2+),optical properties and biological application.In addition,the development prospect of Fe^(2+)fluorescent probes is predicted.