摘要
有氧条件下以NH_(4)OAc/N,N-二甲基甲酰胺(DMF)组合为氰源,发展了Ag/Cu介导芳基羧酸脱羧的氰化反应,并进一步实现了以该方法为关键步骤的吡仑帕奈(perampanel)合成.初步的机理研究表明,产物中的"CN"来源于NH_(4)^(+)/DMF组合,催化体系中的Cu决定着反应的发生,Ag有利于反应的转化.
A Ag/Cu-mediated decarboxylative cyanation of aryl carboxylic acids has been well established using NH_(4)OAc/N,N-dimethylformamide(DMF)as a combined cyanide source under aerobic conditions,and the synthesis of perampanel was further realized with this method as the key step.Preliminary mechanistic investigation indicated the“CN”of desired products was from the combination of DMF and ammonium salt.Cu in the catalytic system was essential for the process,whereas Ag was beneficial for the transformation.
作者
付拯江
郝广果
石泉清
周金琪
姜李高
汪水亮
郭生梅
蔡琥
Fu Zhengjiang;Hao Guangguo;Shi Quanqing;Zhou Jinqi;Jiang Ligao;Wang Shuiliang;Guo Shengmei;Cai Hu(College of Chemistry,Nanchang University,Nanchang 330031;State Key Laboratory of Coordination Chemistry,Nanjing University,Nanjing 210023)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第1期333-340,共8页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21761021,21861026)资助项目.
关键词
脱羧
芳基腈化物
有氧条件
decarboxylation
aryl nitrile
aerobic conditions
