金催化选择性氧化共轭炔基炔酰胺合成4-羰基丁-2-炔酰胺

Gold-Catalyzed Selective Oxidation of 1,3-Diynamides to Access 4-Oxo-but-2-ynamides

通过金催化选择性氧化1,3-共轭炔基炔酰胺,为4-羰基丁-2-炔酰胺化合物的合成提供了一种新的方法.这种含有活化的不饱和炔烃的1,4-双羰基化合物是有机化学中一种重要的合成子.利用该金催化氧化方法,可以高度选择性地对共轭炔烃的1,4-位进行氧化得到2-炔-4-羰基丁酰胺化合物,而不是生成较为常见的1,2-双羰基化合物.在该选择性氧化的条件下,可以以较高的收率得到一系列4-羰基丁-2-炔酰胺化合物.

A gold-catalyzed selective oxidation of 1,3-diynamides has been developed to provide a novel approach to 4-oxo-but-2-ynamides.The products possess activated C-C triple bond,and often serve as versatile building blocks in syn-thetic community.This gold-catalyzed selective oxidation of 1,3-diynamides to provide 4-oxo-but-2-ynamides is noteworthy,since the traditional 1,2-dicarbonyl type products were not observed.Under standard conditions,a range of 4-oxo-but-2-yna mide derivatives were obtained in moderate to high yields.