替格瑞洛治疗急性冠状动脉综合征的临床疗效

The Clinical Efficacy of Ticagrelor in the Treatment of Acute Coronary Syndrome

目的分析探讨替格瑞洛治疗急性冠状动脉综合征的临床疗效。方法方便选取该院心血管内科2019年11月—2020年5月接诊的156例急性冠状动脉综合征患者作为研究对象,按照患者的药物禁忌反应均分为研究组和对照组。两组患者均接受低分子肝素和阿司匹林治疗,对照组在此基础上接受氯吡格雷治疗,研究组在此基础上接受替格瑞洛治疗,进而对两组临床疗效加以比较。结果研究组治疗总有效率(93.59%)高于对照组(82.05%),差异有统计学意义(χ^(2)=4.854,P<0.05);研究组不良反应发生率(5.13%)低于对照组(7.69%),差异无统计学意义(χ^(2)=0.427,P>0.05);治疗前两组患者心绞痛发作次数与持续时间,差异无统计学意义(P>0.05);治疗后两组患者心绞痛发作次数与持续时间均有所改善,且研究组心绞痛发作次数(4.32±1.11)次与持续时间(3.76±1.54)min/次,改善程度优于对照组(5.87±1.07)次、(5.87±1.78)min/次,差异有统计学意义(P<0.05)。结论氯吡格雷与替格瑞洛在急性冠状动脉综合征临床治疗中均有良好的效果,但总体而言,替格瑞洛治疗效果优于氯吡格雷,建议将其作为急性冠状动脉综合征临床治疗的一线选择药物。

Objective To analyze the clinical efficacy of ticagrelor in the treatment of acute coronary syndrome.Methods 156 patients with acute coronary syndrome admitted from the department of cardiovascular medicine in the hospital from November 2019 to May 2020 were conveniently selected as the research objects.According to the drug contraindications of the patients,they were divided into the study group and the control group.Both groups of patients received low-molecular-weight heparin and aspirin treatment,the control group received clopidogrel treatment on this basis,and the study group received ticagrelor treatment on this basis,and the clinical efficacy of the two groups were compared.Results The total effective rate of treatment in the study group was(93.59%)higher than the control group(82.05%),the difference was statistically significant(χ^(2)=4.854,P<0.05);the adverse reaction rate of the study group was(5.13%),lower than that of the control group(7.69%),and the difference was not statistically significant(χ^(2)=0.427,P>0.05);the number and duration of angina pectoris in the two groups before treatment(P>0.05);after treatment,the number and duration of angina pectoris in both groups improved,and the number of angina pectoris in the study group was(4.32±1.11)times,and duration(3.76±1.54)min/time,the degree of improvement was better than that of the control group(5.87±1.07)times and(5.87±1.78)min/time,the difference was statistically significant(P<0.05).Conclusion Clopidogrel and ticagrelor have good effects in the clinical treatment of acute coronary syndromes,but overall,the treatment effect of ticagrelor was better than clopidogrel,and it is recommended to be the first-line choice of drugs for clinical treatment used as an acute coronary syndrome.