依达拉奉结合丙戊酸钠治疗脑卒中后癫痫的疗效分析

Analysis of the Efficacy of Edaravone Combined with Sodium Valproate in the Treatment of Post-stroke Epilepsy

目的探讨依达拉奉+丙戊酸钠治疗脑卒中后癫痫的临床疗效。方法便利选取2018年1月—2019年3月收治的90例脑卒中后癫痫患者为研究对象,随机均等分成对照组和研究组,各45例。对照组以丙戊酸钠治疗,研究组以依达拉奉+丙戊酸钠治疗;比较两组的临床疗效、治疗后癫痫持续发作时间、认知功能等情况、癫痫发作时昏迷程度、日常生活能力。结果治疗后,对照组疗效有效率75.56%、癫痫发作时间(3.42±0.67)min、认知功能(22.64±3.42)分、昏迷程度(8.36±1.45)分、生活能力(54.51±4.27)分;研究组疗效有效率95.56%、癫痫发作时间(2.25±0.34)min、认知功能(25.38±3.61)分、昏迷程度(10.43±1.18)分、生活能力(61.23±4.46)分,两组各项指标比较,差异有统计学意义(χ^(2)=7.283、t=10.446、3.696、7.428、7.301,P<0.05)。结论在常规癫痫治疗的基础上加用依达拉奉药物,患者的癫痫发作情况、癫痫发作持续时间以及癫痫发作时昏迷程度明显减少,认知功能和生活能力得到有效改善。

Objective To explore the clinical efficacy of edaravone and sodium valproate in the treatment of post-stroke epilepsy.Methods A total of 90 patients with post-stroke epilepsy admitted from January 2018 to March 2019 were conveniently selected as the research subjects,and they were randomly divided into a control group and a study group,with 45 cases in each group.The control group was treated with sodium valproate,and the study group was treated with edaravone+sodium valproate;the clinical efficacy,duration of epilepsy after treatment,cognitive function,etc.,degree of coma during epileptic seizures,daily routine were compared between the two groups survival skills.Results After treatment,the control group had an effective rate of 75.56%,seizure time(3.42±0.67)min,cognitive function(22.64±3.42)points,coma degree(8.36±1.45)points,and living ability(54.51±4.27)points.In the study group,the effective rate was 95.56%,seizure time(2.25±0.34)min,cognitive function(25.38±3.61)points,coma degree(10.43±1.18)points,living ability(61.23±4.46)points.Compared the indicators between the two groups,the difference was statistically significant(χ^(2)=7.283,t=10.446,3.696,7.428,7.301,P<0.05).Conclusion With the addition of edaravone drugs on the basis of conventional epilepsy treatment,the patient’s seizures,seizure duration,and coma during seizures are significantly reduced,and the cognitive function and life ability are effectively improved.