多奈哌齐联合丁苯酞治疗老年血管性痴呆的临床效果及对血液流变学的影响

Clinical effect of donepezil combined with butylphthalide in the treatment of senile vascular dementia and its influence on hemorheology

目的探讨多奈哌齐联合丁苯酞治疗老年血管性痴呆的临床效果及对血液流变学的影响。方法选取106例老年血管性痴呆患者,依照随机数字表法将其分为对照组(53例,多奈哌齐)和联合组(53例,多奈哌齐+丁苯酞)。比较两组的治疗效果。结果联合组的治疗总有效率高于对照组(P<0.05)。治疗后,联合组的红细胞压积、全血黏度、纤维蛋白原水平低于对照组(P<0.05)。治疗后,联合组的血清IL-6、IL-1β、TNF-α水平低于对照组(P<0.05)。治疗后,联合组的血清NGF、BDNF水平高于对照组,GFAP水平低于对照组(P<0.05)。结论多奈哌齐联合丁苯酞治疗老年血管性痴呆的临床效果显著,能够改善血液流变学,减轻炎症反应,改善患者的认知功能。

Objective To explore the clinical effect of donepezil combined with butylphthalide in the treatment of senile vascular dementia and its influence on hemorheology.Methods A total of 106 patients with senile vascular dementia were selected and divided into control group(53 cases,donepezil)and combined group(53 cases,donepezil+butylphthalide)according to the random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was higher than that in the control group(P<0.05).After treatment,the hematocrit,whole blood viscosity and fibrinogen level in the combined group were lower than those in the control group(P<0.05).After treatment,the levels of serum IL-6,IL-1βand TNF-αin the combined group were lower than those in the control group(P<0.05).After treatment,the serum NGF and BDNF levels in the combined group were higher than those in the control group,and the GFAP level was lower than that in the control group(P<0.05).Conclusion Donepezil combined with butylphthalide in the treatment of senile vascular dementia has a significant clinical effect,which can improve hemorheology,reduce inflammation response,and ameliorate cognitive function of patients.