固本咳喘方加减联合噻托溴铵治疗尘肺伴慢阻肺的临床效果

Clinical effect of modified Guben Kechuan prescription combined with tiotropium bromide in the treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease

目的探讨固本咳喘方加减联合噻托溴铵治疗尘肺伴慢阻肺的临床效果。方法选择2018年1月至2020年1月收治的100例尘肺伴慢阻肺患者为研究对象,以简单随机化法将其分为对照组(n=50)和试验组(n=50)。对照组给予噻托溴铵,试验组给予固本咳喘方加减联合噻托溴铵。比较两组的临床疗效,治疗前、后的症状积分、肺功能指标及免疫球蛋白指标以及不良反应发生情况。结果试验组的治疗总有效率高于对照组(P<0.05)。试验组治疗后的各项临床症状积分及RV/TLC低于对照组,MVV、FEV1、FVC、MMEF及IgM、IgG、IgA水平高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论固本咳喘方加减联合噻托溴铵治疗尘肺伴慢阻肺,可提高患者的治疗效果,改善其肺功能以及免疫功能,减轻疾病症状,且安全性较高。

Objective To investigate the clinical effect of modified Guben Kechuan prescription combined with tiotropium bromide in the treatment of pneumoconiosis with chronic obstructive pulmonary disease.Methods One hundred patients with pneumoconiosis complicated with chronic obstructive pulmonary disease admitted from January 2018 to January 2020 selected as the research objects and divided into control group(n=50)and experimental group(n=50)according to the simple randomization method.The control group was given tiotropium bromide,and the experimental group was given modified Guben Kechuan prescription combined with tiotropium bromide.The clinical efficacy,symptoms scores,lung function indexes,immunoglobulin indexes before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the control group(P<0.05).After treatment,the clinical symptoms scores and RV/TLC of the experimental group were lower than those of the control group,and the MVV,FEV1,FVC,MMEF,IgM,IgG and IgA levels of the experimental group were higher than those of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Guben Kechuan prescription combined with tiotropium bromide in the treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease can improve the therapeutic effect,lung function and immune function,and reduce disease symptoms of patients,with high safety.