伐昔洛韦联合干扰素α-2b治疗单纯疱疹病毒性角膜炎的效果及安全性

Effect and safety of valaciclovir combined with interferonα-2b in the treatment of herpes simplex keratitis

目的探讨伐昔洛韦联合干扰素α-2b治疗单纯疱疹病毒性角膜炎(HSK)的效果及安全性。方法选择2018年4月至2019年4月我院眼科收治的94例HSK患者为研究对象,随机将其分为对照组和研究组,每组47例。对照组采用伐昔洛韦治疗,研究组在对照组基础上联合干扰素α-2b治疗,比较两组患者的临床疗效、症状消失时间、疼痛程度及不良反应发生情况。结果研究组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。研究组的角膜愈合时间以及疱疹结痂时间显著短于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者的VAS评分均低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05)。对照组的不良反应总发生率为8.51%,高于研究组的4.26%,但差异无统计学意义(P>0.05)。结论伐昔洛韦联合干扰素α-2b治疗HSK的效果显著,安全性较高,值得在临床推广和应用。

Objective To investigate the effect and safety of valaciclovir combined with interferonα-2b in the treatment of herpes simplex keratitis(HSK).Methods A total of 94 HSK patients admitted to the ophthalmology department of our hospital from April 2018 to April 2019 were selected as the research objects and randomly divided into control group and study group,with 47 cases in each group.The control group was treated with valaciclovir,while the study group was treated with interferonα-2b on the basis of the control group.The clinical efficacy,symptom disappearance time,pain degree and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The corneal healing time and herpes scab time in the study group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the VAS scores of the two groups were lower than that before treatment,and that in the study group was lower than the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the control group was 8.51%,which was higher than 4.26%in the study group,but the difference was not statistically significant(P>0.05).Conclusion Valaciclovir combined with interferonα-2b in the treatment of HSK has a significant effect and high safety,which is worthy of clinical promotion and application.