丙种球蛋白联合双嘧达莫对非典型川崎病患儿的治疗效果研究

Therapeutic Effect of Gamma-Globulin Combined with Dipyridamole in the Treatment of Atypical Kawasaki Disease in Children

目的:探讨丙种球蛋白联合双嘧达莫对非典型川崎病患儿的治疗效果。方法:选取2017年1月至2020年1月于北京市海淀医院就诊的非典型川崎病患儿64例,按照完全随机法分为对照组、观察组,每组32例。两组患儿入院时均给予对症治疗;对照组患儿在此基础上给予丙种球蛋白治疗;观察组患儿在对照组的基础上给予双嘧达莫治疗。比较两组患儿的相关症状、体征(发热、黏膜充血、颈淋巴结肿大和手足肿胀)消失时间,检测两组患儿白细胞计数(WBC)、血小板计数(PLT)、C反应蛋白(CRP)及降钙素原(PCT)水平,并观察治疗效果和不良反应发生情况。结果:观察组患儿治疗后退热时间、黏膜充血消失时间,颈淋巴结肿大消退时间和手足肿胀消退时间均明显短于对照组,差异均有统计学意义(P<0.05)。观察组患儿治疗后的WBC、PLT水平明显低于对照组,CRP、PCT水平明显低于对照组,差异均有统计学意义(P<0.05)。观察组患儿的总有效率为93.75%(30/32),明显高于对照组的71.88%(23/32),差异有统计学意义(P<0.05)。观察组、对照组患儿的不良反应发生率分别为28.13%(9/32)、34.38%(11/32),差异无统计学意义(P>0.05)。结论:丙种球蛋白联合双嘧达莫用于非典型川崎病患儿的疗效显著,有助于控制炎症反应,促进患儿身体健康的恢复。

OBJECTIVE:To probe into the therapeutic effect of gamma-globulin combined with dipyridamole in the treatment of atypical kawasaki disease in children.METHODS:Totally 64 children with atypical kawasaki disease admitted into Beijing Haidian Hospital from Jan.2017 to Jan.2020 were selected and divided into control group and observation group via completely random method,with 32 cases in each group.Both groups were given symptomatic treatment on admission;the control group was given gamma-globulin on that basis;the observation group was given dipyridamole based on the control group.Children in the two groups were compared in terms of the disappearance time of symptoms and signs(fever,mucous membrane congestion,swollen cervical lymph nodes,swollen hands and feet),the white blood cell count(WBC),platelet count(PLT),C-reactive protein(CRP)and calcitoninogen(PCT)levels were measured,and the therapeutic effect and adverse drug reactions were observed.RESULTS:The fever remission,mucosal congestion disappeared,cervical lymph node enlargement subsided,hand and foot swelling subsided of children in the observation group were significantly shorter than those in the control group,with statistically significant differences(P<0.05).The WBC and PLT levels of children in the observation group were significantly lower than those in the control group,the CRP and PCT levels were significantly lower in the observation group than the control group after treatment,with statistically significant differences(P<0.05).The total effective rate of children in the observation group was 93.75%(30/32),which was significantly higher than that of the control group(71.88%,23/32),with statistically significant difference(P<0.05).The incidences of adverse drug reactions of children in observation group and control group were respectively 28.13%(9/32)and 34.38%(11/32),with no statistically significant difference(P>0.05).CONCLUSIONS:The efficacy of gamma-globulin combined with dipyridamole in the treatment of atypical kawasaki disease is remarkable,which helps to control the inflammatory reaction and promote the recovery of children’s health.